摘要
作者对流行性出血热(EHF)各期患者全血粘度(WBV)、血浆粘度(PV)、红细胞压积(Ht)、全血还原粘度(RWBV)、红细胞电泳时间及电泳率等8项血液流变学指标进行了测定,同时检测患者脂质过氧化(LPO)降解产物丙二醛(MDA)的含量.结果发现,EHF患者在整个病程中血液流变学指标有很大变化WBV(230 s^(-1),5.75 s^(-1)),PV,Ht在休克期较正常升高,其数值分别为5.92±0.90,17.28±3.30,1.72±0.20,5253±9.50,自少尿期开始又低于正常,其变化基本与病情相符;除发热期外,各期患者血清MDA值均高于正常(P<0.05-0.01);在EHF不同病期,MDA与血液流变学部分指标相关.作者认为动态观察血液流变学变化规律,对探讨发病机理、合理用药具有一定意义.
Fifty patients with epidemic hemorrhagic fever (EHF )were checked with eight indices of hemorrheology . At the same time , MDA , the degradation product of lipid peroxidation (LPO ) has also been detected . The outcomes indicate that indices of hemorrheology change greatly in the course of EHF whole blood viscosity (230 s-1. 5.75 s-1),plasma viscosity and hematocrit were higher in hypotensive phase , compared with control group,each of them was 5.92 ± 0.90 17.28± 3.30, 1.72± 0.20, 5253 ± 9.50, after that they were lower than normal person . Serum MDA level rose considerably in every phase except the first one (P<0.05-0.01). Some of which were correlated with LPO in different phases of the disease (P<0.05). The results suggest that the dynamic observation of hemorrheology alteration so as to find out the rule of its hcmorrheologic parameters change is valuable in studying pathogenesis and judging the severity of the disease . To correct the change of hemorrheology and free radical reaction in the patients may be benificial to their recovery .
出处
《第四军医大学学报》
1991年第4期266-268,共3页
Journal of the Fourth Military Medical University
关键词
流行性出血热
血液流变学
hemorrhage fever, epidemic
hemorrheology, lipid peroxidation
