摘要
本文应用微机辅助的体视学方法,对大鼠冲击伤后肺的病理形态与功能变化进行了定量分析。结果如下:(1)形态计量学指标与血气分析结果相关;(2)肺泡上皮及毛细血管内皮细胞结构的变化是血气屏障算术平均及调和平均厚度(Tat,Tht)增加的主要原因,间质的变化对其无明显影响;(3)几个主要血气指标在反映肺脏病理变化的体视学参数上的回归方程分别是: 最后,讨论了这种定量对比研究的意义及应用。
The morphological and functional changes of the lungs of rats in blast injury were analyzed and related with a microcomputer-assisted morpho-metry.The results were as follows:1.Significant correlation or partial correlation existed between stereological and functional indices,2.Changes of endothelium and epithelium rather than the interstitium contributed to the increase of harmonic and arithmetic mean thickness of the air-blood barrier.3.The regression equations included the following:a.PaO2=3.56 + 1.62DL (O2),r=0.678,P=0.032b.PaO2=2.99+3.49DL(O2)-0.0005SA+0.0035SC-38.2VC-0.257Tap -0.028Dt (O2)ry=0.999,P=0.008c.PaCO2=7.69+0.0001SA-4.35Tat+19.7Tht-46.2Thp-4.4Taen-5.87Tacp ry=0.9999,P=0.014d.pH=3.058 + 0.0005SA-1.79Tat + 12.2Tht-50.8Thp-2.52Taent+0.69DL(O2)ry=0.9999,P=0.01The significance and application of stereology in the establishment of the quantitative relationship between morphological and functional indices were discussed.It is possible to correlate morpheme trie parameters with the functional changes of an organ.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第5期434-438,共5页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
肺
体视学
冲击伤
病理学
lung/PA
blast injuries
stereology
