摘要
胰岛素相对不足和组织胰岛素抵抗是引起烧伤后高分解代谢的重要原因本研究针对此原因。在动物实验的基础上,对口服甲磺丁脲的烧伤病员连续观察10d。结果表明该药能通过以下3个方面改善烧伤高代谢:(1)刺激胰岛素释放,强化胰岛素作用,(2)促进组织对葡萄糖的摄取和利用,(3)抑制胰高血糖素的释放。
Relative deficiency of serum insulin and insulin resistance of tissues are the main causes of postburn hypercatabolism.In order to evaluate the clinical effects of tolbutamide to improve postburn hypermetabolism,9 burn patients were given tolbutamide and observed for 10 days after the drug had gone through animal experiments.It was found that tolbutamide could improve postburn hyper-metabolism through following ways:1.To stimulate the secretion of insulin and enhance the effect of insulin.2.To reduce the insulin resistance of tissues and promote glucose utilization of skeletal muscles.3.To inhibit the secretion of glucagon.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第4期317-320,共4页
Journal of Third Military Medical University
