摘要
目的探讨阿托伐他汀致不良反应(ADR)的一般规律与特点。方法对福建省长乐市医院2008年1月—2012年6月上报的阿托伐他汀所致10例ADR报告表进行统计、分析。结果阿托伐他汀引起的ADR中,女性7例,男性3例。发生次数最多为心肌、心内膜、心包及瓣膜损害3次(17.65%),肝胆系统损害3次(17.65%)、全身性损害2次(11.76%)、中枢及外周神经系统损害2次(11.76%)、胃肠系统损害2次(11.76%)。结论临床上应加强阿托伐他汀应用的监测,以减少不良反应的发生。
Objective To explore the general rules and characteristics of the adverse reactions（ADR） caused by Atorvastatin. Methods Ten cases of ADR reduced by Atorvastatin in Fujian Changle Hospital from January 2008 to June 2012 were reported and statistically analyzed. Results In the 10 cases of ADR reduced by Atorvastatin （female 7 cases and male 3 cases）, the myocardial, endocardial, pericardial and valvular damage and the hepatobiliary system damage were most frequently occurred （for three times, 17.65%, respectively）, followed by the systemic damage （twice, 11.76%）, the central and peripheral nervous system damage （twice, 11.76%）, and the gastrointestinal system damage （twice, 11.76%）. Conclusion The clinical application of Atorvastatin should be monitored , in order to reduce the occurrence of ADR.
出处
《药物评价研究》
CAS
2013年第3期215-217,共3页
Drug Evaluation Research
关键词
阿托伐他汀
不良反应
临床用药
Atorvastatin
adverse reactions
clinical medication
