摘要
雄性家兔11只,随机分为生理盐水治疗组(等盐组,n=5)和高渗盐水治疗组(高盐组,n=6)。于模拟海拔4000m急性缺氧条件下,经股动脉放血,使动脉平均压降至6.00±0.27kPa,维持此水平60min后,于夹闭放血管10min时,经股静脉输入总失血量1/10的生理盐水或高渗盐液(7.5％)。结果表明,高渗盐液可明显增加模拟高原条件下急性失血性休克动物的平均动脉压(MAP)和左室收缩压(LVSP),提高左室压最大上升速率(LV+dp/dt max),延长存活时间和提高存活率。提示高渗盐液能够改善模拟高原条件下失血性休克机体的心血管功能。其机制可能与增加的血浆钠离子浓度增强心肌收缩力和降低血管阻力有关。
Eleven male rabbits were divided into 2 groups. Normal saline(NS) group consisted of 5 animals and was treated with 0.9% NaCl solution, and hyperosmotic saline (HS) group consisted of 6 rabbits and was treated with 7.5% NaCl. The animals were exposed to hypobaric hypoxia at a simulated altitude of 4000 m and hemorrhagic shock was inflicted to them through femoral artery bleeding. The mean arterial pressure (MAP) was brought to 6.0 kPa over 10 minutes and kept at that level for 70 minutes. A certain amount of 0.9% NaCl (300 mmol/L) or 7.5% NaCl (2400 mmol/L) was intravenously infused over a 10-minute interval. The volume infused was equivalent to 10% of the total blood shed. It was found that MAP, left ventricular systolic pressure, and LV dp/dt were significantly higher in HS group than in NS group (from 3rd to 20th minute after infusion). Sodium ion concentration was significantly higher in HS (145.8±3.16 mmol/L) than in NS (135.6±2.87 mmol/L) (P<0.05). The surviving time of the 5 rabbits of NS group was 4.5, 28, 40, 70 and 100 minutes respectively, but only 2 of the 6 rabbits of HS group died at the 100th minute after infusion. Thus the survival rate at the 120th minute was 0 % and 66% in NS and HS respectively.The results suggest that hyperosmotic saline could elevate arterial pressure, lengthen surviving time and increase survival rate of the rabbits with hemorrhagic shock at a simulated altitude of 4000 m. These effects might be related to the increased plasma concentration of sodium ions which could strengthen myo-cardial contraction and diminish vascular resistance.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第2期131-135,共5页
Journal of Third Military Medical University
关键词
休克
高原
高渗盐水
失血性
Shok, hemorrhagic/DT
altitude
solution, hypertonic
cardiovascular function
