摘要
本文初步观察了正常人中分子物质(N-MMS)和烧伤病人中分子物质(B-MMS)对正常人红细胞膜Ca^(2+)-ATP酶活力的影响。结果表明,不同保温时间N-MMS对红细胞膜Ca^(2+)-ATP酶活力有明显影响,保温时间越长酶活力抑制越显著(p<0.01),对照组变化不明显;不同浓度N-MMS和B-MMS对红细胞膜Ca^(2+)-ATP酶活力均有影响,浓度越高酶活力抑制越明显(P<0.01)。MMS对质膜Ca^(2+)-ATP酶的抑制作用可能是MMS导致细胞病理变化的一个重要环节。
The effect of plasma middle molecule substances (MMS) on the Ca2+-ATPase activity in human erythrocyte membranes was studied. The results showed that the Ca2+-ATPase activity was significantly inhibited when the membrane preparation was incubated with MMS at 37℃. The longer the period of time for incubation, the lower the Ca2+-ATPase activity. The activity of Ca2+-ATPase could be significantly inhibited by plasma MMS of both normal person and burn patient. The inhibitory rate (%) of Ca2+-ATPase activity was elevated markedly when MMS concentration was increased (P<0.01). The results suggest that the inhibitory effect of MMS on the Ca2+-ATPase activity in cell membrane may play an important role in cell pathological changes.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1991年第6期530-533,共4页
Academic Journal of Second Military Medical University
关键词
中分子物质
红细胞膜
酶
middle molecule substances
erythrocyte membrane
Ca2+-ATPase
