摘要
控制细胞内关键信号传导通路是病毒在感染过程中调控众多细胞功能的一种重要方式。PI3K-Akt是细胞内重要的信号通路,一些病毒利用该信号通路与宿主免疫系统进行博弈,进而成功实现对宿主细胞的感染,胁迫宿主细胞为其复制增殖服务,并且最终导致宿主生理代谢功能紊乱,甚至是诱发癌症生成。因此,了解PI3K-Akt信号通路在病毒感染过程中的调控作用,对理解一些病毒感染及发病机制,以及相关病毒疾病的预防和治疗具有重要意义。综述PI3K-Akt信号通路与病毒感染的相关研究进展。
Many viruses have developed the ability to modulate key signaling pathways,and govern host cell functions to facilitate its proliferation.PI3K-Akt pathway is one of these key pathways which participate in host-pathogen interaction.Viruses take advantage of this pathway to create an environment favourable for its replication,resulting in dysfunction of the host cells,or even carcinogenesis.A thorough study on the roles of PI3K-Akt pathway in virus infection is of great significance to comprehensively understand pathogenesis,prevention and treatment of virus diseases.In this review,we summarize the recent advances in research on the regulation of PI3K-Akt signaling during virus infection.
出处
《生物技术通报》
CAS
CSCD
北大核心
2013年第6期53-62,共10页
Biotechnology Bulletin
基金
福建省自然科学基金项目(2011J05079)
现代农业产业技术体系专项资金(CARS-47)
