期刊文献+

人附睾蛋白4(HE4)在卵巢癌的诊断及预后研究的新进展 被引量:1

The progress of human epididymis protein 4 in diagnosis and prognosis of ovarian cancer
暂未订购
导出
摘要 人附睾蛋白4(HE4)是妇科恶性肿瘤领域近年研究的热点,日益增多的研究表明,HE4在卵巢癌的诊断及疾病监测方面具有很好的应用前景,HE4与CA125的联合检测,可提高诊断的敏感性和特异性,同时对卵巢癌的预后具有较好的提示作用。 Human epididymis protein 4 (HFA) is one of the most focused tumor markers in the research of gynecology malignancy. Increasing number of studies have shown that HE4 has a good application prospect in early diagnosis, differentiential diagnosis, and diseased surveillance of ovarian cancer. HE4 combined with CA125 can improve the sensitivity and specificity of the diagnosis, and may be helpful in the prognosis assessment of ovarian cancer. It may have wider application field.
作者 唐志坚 崔恒
出处 《实用肿瘤学杂志》 CAS 2013年第3期193-197,共5页 Practical Oncology Journal
关键词 人附睾蛋白4 卵巢癌 肿瘤标志物 CA125 Human epididymis protein 4 Ovarian cancer Tumor markers CA125
  • 相关文献

参考文献23

  • 1Kirchhoff C, Habben I, Ivell R, et ah A major human epidid- ymis- specific cDNA encodes a protein with sequence ho- mology to extracellular pmteinase inhibitors [ J ]. Biol Re- prod, 1991,45 (2) :350 - 357.
  • 2Sehummer M, Ng WV, Bumgarner RE, et al. Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas[ J]. Gene, 1999,238 (2) :375 - 385.
  • 3Drapkin R, van Horsten HH, Lin Y, et al. Human epididymis protein 4 (HE4)is a secreted glycoprotein that is overex- pressed by serous and endometrioid ovarian carcinomas[ J]. Cancer Res, 2005,65 (6) : 2162 - 2169.
  • 4Galgano MT, Hampton GM, Frierson HF JR. Comprehensive analysis of HFA expression in normal and malignant human tissues [ J ]. Mod Pathol,2006,19 (6) :847 - 853.
  • 5Anderson GL, Mclntosh M, Wu LL, et al. Assessing lead time of selected ovarian cancer biomarkers : A nested case - control Study[ J]. J Natl Cancer Inst,2010,102(l) :26 - 38.
  • 6Hellstram I, Raycraft J, Hayden - Ledbetter M, et al. The HE4 (WFDC2)protein is a biomarker for ovarian carcinoma [ J ]. Cancer Res ,2003 ,63 ( 13 ) : 3695 - 3700.
  • 7Shah CA, Lowe KA, Paley P, et al. Influence of ovarian cancer risk status on the diagnostic performance of the ser- um biomarkers mesothelin, HE4, and CA125 [ J ]. Cancer Epidemiol Biomarkers Prey,2009,18 ( 5 ) : 1365 - 1372.
  • 8Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcino- ma in patients with a pelvic mass[ J]. Gynecol Oncol,2008, 108 (2) :402 - 408.
  • 9Havrilesky LJ, Whitehead CM, Rubatt JM, et al. Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence [ J ]. Gynecol Oncol, 2008, 110 (3) :374 - 382.
  • 10董丽,昌晓红,叶雪,朱丽荣,赵旸,田莉,程洪艳,李小平,张虹,廖秦平,付天云,成夜霞,崔恒.血清人附睾分泌蛋白4和CA125水平检测在卵巢恶性肿瘤中的诊断价值[J].中华妇产科杂志,2008,43(12):931-936. 被引量:98

二级参考文献38

  • 1Gadducci A, Cosio S, Carpi A, et al. Serum tumor markers in the management of ovarian, endometrial and cervical cancer. Biomed Pharmacother,2004,58 : 24 -38.
  • 2Meyer T, Rustin GJ. Role of tumour markers in monitoring epithelial ovarian cancer. Br J Cancer,2000,82 : 1535-1538.
  • 3Hellstrom I, Raycraft J, Hayden-Ledbetter M, et al. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res, 2003,63 : 3695 -3700.
  • 4Israeli O, Goldring-Aviram A, Rienstein S, et al. In sihco chromosomal clustering of genes displaying altered expression patterns in ovarian cancer. Cancer Genet Cytogenet,2005 ,160 :35- 42.
  • 5Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 ( HE4 ) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res, 2005, 65:2162-2169.
  • 6Kirchhoff C, Habben I, Ivell R, et al. A major human epididymisspecific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Biol Reprod, 1991,45: 350- 357.
  • 7Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol,2008,108:402-408.
  • 8Bast RC Jr, Klug TL, St John E, et al. A radio ty using a monoclonal antibody to monitor the course of epithelial ovarian cancer[ J ]. N Engl J Med, 1983,309:883- 887.
  • 9Jacobs I, Bast RC Jr. The CA 125 tumor-associated antigen : a review of the literature [ J ]. Hum Reprod, 1989,4 : 1- 12.
  • 10Jacobs I, Oram D, Fairbanks J, et al. A risk of malignancy index incorporating CA125 ,ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer [J]. Br J Obstet Gynaecol, 1990,97:922-929.

共引文献185

同被引文献7

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部