期刊文献+

肝癌患者联合检测血清甲胎蛋白及B淋巴细胞瘤2和热休克蛋白70意义研究

暂未订购
导出
摘要 目的探讨联合检测原发性肝癌患者血清甲胎蛋白(AFP)、B淋巴细胞瘤2(bcl-2)、热休克蛋白70(HSP70)水平在肝癌诊断的敏感性。方法 60例肝癌患者、60例肝硬化及60例正常人对照者血清,采用ELISA法检测血清AFP、bcl-2、HSP70水平,根据450nm酶标仪扫描结果,标准样浓度和OD算出各样本浓度(ng/ml)。结果 3组AFP、bcl-2、HSP70水平比较,差异均有统计学意义(P<0.05);其中,肝硬化组和对照组较肝癌组AFP、bcl-2、HSP70水平明显降低,差异有统计学意义(P<0.05);对照组较肝硬化组AFP、bcl-2、HSP70水平明显降低,差异有统计学意义(P<0.05)。结论 AFP、bcl-2、HSP70在原发性肝癌人群血清中高表达,随肿瘤侵袭度增高表达呈上升趋势,联合检测在肿瘤恶性生物学评估、判断预后等方面具有重要的意义。
出处 《临床合理用药杂志》 2013年第18期31-31,共1页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

参考文献1

二级参考文献11

  • 1Trisciuoglio D,Iervolino A,Zupi G,et al.Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells[J].Mol Biol Cell,2005,16(9):4153~4162
  • 2Gysin S,Lee SH,Dean NM,et al.Pharmacologic inhibition of RAF-》MEK-》ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1[J].Cancer Res,2005,65(11):4870~4880
  • 3Zhang H,Vollmer M,De Geyter M,et al.Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK[J].Int J Oncol,2005,26(6):1575~1580
  • 4Ciampi R,Knauf JA,Kerler R,et al.Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer[J].J Clin Invest,2005,115(1):94~101
  • 5Fire A,Xu S,Montgomery MK,et al.Potent and specific genctic interference by double stranded RNA in C[J].elegans,Nature,1998,391 (6669):806~811
  • 6Parrish S,Fleenor J,Xu S,et al.Functional anatomy of a dsRNA trigger:differential requirement for thc two trigger strands in RNA interference[J].Molecular Cell,2000,6 (5):1077~1087
  • 7Grishok A,Pasquinelli A,Conte D,et al.Genes and mechanisms related to RNA interference regulate expression of the small tem poral RNAs that control C.elegans developmental timing[J].Cell,2001,106(1):23~34
  • 8Caplen N,Parrish S,Imani F,et al.Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems[J].Proc Natl Acad Sci USA,2001,98 (17):9742~9747
  • 9Elbashir SM,Harborth J,Lendeckel W,et al.Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells[J].Nature,2001,411 (6836):494~498
  • 10Shimada K,Nakamura M,Ishida E,et al.Molecular rolcs of MAP kinases and FADD phosphorylation in prostate cancer[J].Histol Histopathol,2006,21(4):415~422

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部