摘要
目的探讨他汀类药物治疗阵发性心房颤动的预后及临床效果。方法将2011年3月~2012年1月来深圳市龙华新区观澜人民医院诊治的伴有阵发性心房颤动的患者60例随机分为治疗组和对照组,每组各30例。治疗组采用阿托伐他汀钙片进行治疗,对照组采用常规拜阿司匹林抗血小板聚集治疗。观察两组患者入选时及治疗3、6、12个月后的房颤发作频度及持续时间,同时记录两组患者的阵发性房颤发生率、超敏C反应蛋白水平、低密度脂蛋白胆固醇水平以及患者的再住院率和致残率。结果治疗后3、6个月,两组患者阵发性房颤发生率比较差异无统计学意义（P〉0.05）,而治疗12个月后再次随访,发现治疗组阵发性房颤发生率（12.8%）明显低于对照组（46.2%）,差异有统计学意义（P〈0.05）。治疗组治疗后超敏C反应蛋白和低密度脂蛋白胆固醇水平均显著低于对照组（P〈0.05）。治疗组的再住院率及致残率均显著低于对照组（P〈0.05）。结论他汀类药物对阵发性心房颤动的预后良好,可以抑制炎症反应,减少阵发性房颤复发,还能降低患者的再入院率及致残率,值得在临床推广应用。
Objective To investigate the prognosis and clinical efficacy of statins in the treatment of paroxysmal atrial fibrillation. Methods 60 patients with paroxysmal atrial fibrillation in Guanlan People＇s Hospital of Longhua District in Shenzhen City from March 2011 to January 2012 were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was treated with Atorvastatin Calcium Tablets, while the control group was treated with traditional treatment of Bayaspirin for anti-platelet aggregation. After 3, 6, 12 months, the incidence of paroxysmal atrial fibrillation, hs-CRP level, LDL-C level, the patient＇s readmission rate and disability rate of the two groups were recorded. Results After treatment for 3, 6 months, the incidence of paroxysmal atrial fibrillation of the two groups was not statistically significant （P 〉 0.05）. However, after treatment for 12 months, during follow-up, the incidence of paroxysmal atrial fibrillation in treatment group （12.8%） was significantly lower than control group （46.2%）, the difference was statistically significant different （P 〈 0.05）. The hs-CRP and LDL-C level of treatment group were significant lower than those of control group （P 〈 0.05）. The readmission rate and disability rate of treat- ment group were significant lower than those of control group （P 〈 0.05）. Conclusion Statins treatment can reduce the relapse of paroxysmal atrial fibrillation, and it is also secure and effective. It is worthy of clinical application.
出处
《中国医药导报》
CAS
2013年第20期63-65,共3页
China Medical Herald
基金
广东省深圳市宝安区科技计划社会公益项目(编号2012300)
关键词
他汀类药物
阵发性房颤
疗效
Statins
Paroxysmal atrial fibrillation
Efficacy
