摘要
目的探讨瑞芬太尼术后镇痛对大肠癌患者术后T细胞亚群的影响。方法 5年间对本院普外科行大肠癌根治术的120例符合筛选条件患者为研究对象,随机分为对照组65例未采用术后镇痛,观察组55例采用瑞芬太尼术后镇痛,分别于麻醉前、术后12h、术后24h、术后48h监测两组患者T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平变化。结果两组患者术后麻醉前细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平变化比较(t=2.34、2.11、2.16、1.77,P>0.05,差异无统计学意义);两组患者术后12h、24h、48hT细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)水平变化比较(t=6.34、5.78、3.56、6.77,P<0.05,差异有统计学意义)。结论瑞芬太尼术后镇痛能有效抑制术后疼痛并改善患者的细胞免疫功能。
Objective Effect of analgesia on postoperative patients with colorectal cancer T cell subsets after Reminfentanil postoperative. Methods 5 years in our hospital department of general surgery colorectal cancer who underwent radical 120 patients met the screening criteria patients as the research object, randomly divided into a control group of 65 cases without postoperative analgesia, to observe the analgesia using remifentanil group and 55 cases of postoperative, respectively before anesthesia, 12 h after operation, postoperative 24 h, patients with 48 h monitoring two groups of T cells subsets （CD＋3, CD＋4, CD＋8, CD＋4 / CD＋8） level. Results of the two groups of patients with preoperative cell subsets （CD＋3, CD＋4, CD＋8, CD＋4 / CD＋8） level changes （t=2.34, 2.11, 2.16, 1.77, P0.05, no significant difference）; the two groups of patients with 12 h, 24 h, 48 h, T cell subsets （CD＋3, CD＋4, CD＋8, CD＋4 / CD＋8） level changes （t=6.34, 5.78, 3.56, 6.77, P0.05, with significant difference）. Conclusion postoperative analgesia with remifentanil can inhibit the improvement of cellular immune function in patients with postoperative pain and.
出处
《中国实用医药》
2013年第16期51-52,共2页
China Practical Medicine
关键词
瑞芬太尼
大肠癌
免疫功能
Remifentanil
Colorectal cancer
Immune function
