摘要
目的探讨间苯三酚联合氨甲环酸在晚期先兆流产中的应用效果。方法选择2011年7月—2012年12月收治的晚期先兆流产孕妇526例,随机分为观察组和对照组各263例,观察组给予间苯三酚80-120 mg加入5%葡萄糖注射液250 ml静脉滴注,对照组给予25%硫酸镁注射液40 ml加入5%葡萄糖注射液250 ml静脉滴注。两组滴速均30-40滴/min,每日用量均≤200 mg,均连续用药3-7 d。有阴道流血的患者均联合应用氨甲环酸100 ml静脉滴注,用药时间≤3 d。比较两组疗效及不良反应发生情况。计量资料采用t检验,计数资料采用χ2检验,P〈0.05为差异有统计学意义。结果总有效率观察组为92.02%,对照组为81.37%,两组比较差异有统计学意义（χ2=12.919,P〈0.05）。观察组无一例发生不良反应,对照组发生潮热、口干、恶心呕吐、头痛、发热等不良反应共157例,占59.70%,两组不良反应发生率比较差异有统计学意义（χ2=223.799,P〈0.05）。结论间苯三酚联合氨甲环酸治疗晚期先兆流产安全有效,不良反应小,患者易于接受,值得临床推广。
Objective To study the clinical efficacy of phloroglucinol combined with tranexamic acid in late-term threatened abortion.Methods A total of 526 treated cases of late-term threatened abortion from July 2011 to December 2012 were random- ly divided into observation group and control group, 263 cases for each.For observation group,80 to 120 mg of phloroglucinol in- jection （the daily dose ≤ 200 mg）added in 250 ml of 5% glucose solution was administered at a rate of 30to40 drops per minute. For control group, 25% magnesium sulfate injection（the daily dose ≤200 mg）added in 250 ml of 5% glucose solution was admin- istered at a rate of 30-40 drops per minute. Both groups were treated for 3to7 d.For patients with vaginal bleeding in both groups, intravenous tranexamic acid（100 ml） should be given in combination for no more than three days.Clinical efficacy and adverse re- actions were compared in both groups.Chi-square test was used for count data, the result of P〈0.05 was considered statistically significant.Results The total effective rate was 92.02% in observation group and 81.37% in control group,which showed signifi- cant difference between the two groups （X^2=12.919,P〈0.05）.No case of adverse reactions occurred in observation group,and hot flashes,dry mouth,nausea and vomiting,headache,fever and other adverse reactions developed in 157 cases,accounting for 59.69%, and significant difference was found between the two groups （X^2=223.799,P〈0.05）.Conclusion Phloroglucinol combined with tranexamic acid for late-term threatened abortion is of effectiveness,safety,less adverse reactions and well acceptance by patients, which is worthy of being applied in clinical practice.
出处
《社区医学杂志》
2013年第11期41-43,共3页
Journal Of Community Medicine
关键词
先兆流产
晚期
间苯三酚
氨甲环酸
硫酸镁
Threatened abortion
Late-tem
Phloroglucinol
Tranexamic acid
Magnesium sulfate
