摘要
研究分娩活跃期静脉注射安定对新生儿的影响，选择１９９２年９月至１９９３年２月间在我院住院正常足月临产妇６０例，随机分安定组与对照组，各３０例。安定组妇于宫颈扩张活跃期、宫口开大至３～５ｃｍ时静脉注射安定１０ｍｇ。采用高速液相色谱法检测胎儿娩出时脐血及母血药物浓度，并进行新生儿Ａｐｇａｒ评分及脐动脉血气分析。结果：娩出寸新生儿脐血安定浓度高于母血，去甲基安定浓度低于母血（Ｐ＞０．０５）；安定组与耐照组脐动脉血血气无明显差异（Ｐ＞０．０５）；安定组新生儿肌张力抑制和呼吸抑制友生率分别是６３．３％和２６．７％，均明显高于对照组的３０．０％和３．３％（Ｐ＜０．０１，Ｐ＜０．０５）。提示：活跃期静脉注射安定对新生儿有一定抑制作用。
Objectlve To investigate the effects of diazepam on the neonates administered intravenously during the active phase in labour. Methods Sixty normal term parturients during the active phase of labour with the cervical di-latation to 3～5cm were randomly divided into two groups,study group(n=30)and control group(n=30).In study group 10mg diazepam was administered intravenously,The concentrations of di-azepam and demethyldiazepam in maternal and cord serum were measured by high performance liquid chromatography and neonatal arterial blood gas and Apgar scoring were determined immediately after birth. Results At delivery,the mean level of diazepam in umbilical cord serum was 947 ± 314μg/L,markedly higher than that of maternal serum which was 488±300μg/L, while the mean levels of demethyldiazepam were not significantly different in maternal and fetal serum, There was n0 marked difference between the two groups in fetal arterial blood gas and acidbase status,However,the rates of respiratory depression and muscle tone inhibition in the neonates of study groups(63.3%and 26.7%respectively)were significantly higher than those in the control group(30%and 3.3%re-spectively)(P<0. 05, P<0.01)。Conclusions Use of diazepam in pregnant women during active phase of la bour may cause de-pression of neonatal respiration.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1995年第12期707-710,共4页
Chinese Journal of Obstetrics and Gynecology
关键词
安定
第一产程
新生儿
阿普加评分
Diazepam Labour stage,first Infant, newborn Apgar score Fetal blood
