摘要
[目的]探讨经内镜胆道支架置入内引流(ERBD)术治疗晚期恶性梗阻性黄疸的临床疗效及其对细胞免疫功能的影响。[方法]收集2009年1月至2012年12月间接受ERBD术的晚期恶性梗阻性黄疸患者的临床资料并随访。[结果]58例中51例成功置入支架,成功率为87.9%。支架置入组患者术后黄疸逐渐消退,皮肤瘙痒等症状明显缓解或消失,术后3d、1周血清TB、DB、AST、ALT、ALP、GGT各项指标与术前相比均明显下降(P均<0.05)。术后细胞免疫功能逐步改善,与术前比较术后2周的CD3+、CD4+、CD4+/CD8+水平明显升高(P均<0.05)。[结论]ERBD术治疗恶性胆道梗阻疗效确切,同时能一定程度地改善患者细胞免疫功能,对提高患者生存质量,延长生命具有较满意效果。
Purpose To explore the curative effect of endoscopic retrograde biliary drainage （ERBD） in the treatment for patients with malignant obstructive jaundice and its influence on the cellular immunity. Methods The data of patients with advanced malignant obstructive jaundice undergoing ERBD from January 2009 to December 2012 were collected and followed up. Results The successful rate of stent insertion was 87.9% （51/59）.The jaundice gradually degraded,and the symptoms such as pruritus remited in 51 patients after ERBD. TB,DB,AST, ALT,ALP and GGT decreased significantly at 3 days after ERBD,also 1 week after ERBD （P0.05）.The cellular immunity improved. The levels of CD3＋,CD4＋and CD4＋/CD8＋ increased sig- nificantly at 2 weeks after ERBD compared to those at preoperation（P0.05）.Conclusions The curative effect of ERBD in the treatment for patients with malignant obstructive jaundice is certain. ERBD could partially improve the cellular immuneity and quality of life for the patients, and prolong survival.
出处
《肿瘤学杂志》
CAS
2013年第6期484-487,共4页
Journal of Chinese Oncology
