摘要
早产是一个复杂的医学及社会问题,与围生儿发病率及死亡率直接相关。产科学者为早产的防治做了大量的研究,提出了多种预测早产的方法,如胎儿纤维连接蛋白、胰岛素样生长因子结合蛋白1、血清松弛素、羊水、宫颈分泌物中相关的蛋白质因子以及宫颈超声检查等。治疗方面,宫缩抑制剂可以使妊娠妇女延迟48 h分娩,给予了皮质类固醇起效及宫内转运的时间,当前推荐使用的有β肾上腺素受体激动剂、缩宫素受体拮抗剂、钙通道拮抗剂、硫酸镁、孕激素制剂及环氧化酶抑制剂等。对近年来早产防治的研究进展进行综述,评估可临床应用的早产预测因子及宫缩抑制剂。
Premature birth is considered the main cause of neonatal morbidity and mortality,remains a complex medial and social problem.Obstetric scholars have done a lot of researches on many aspects to predict and prevent preterm birth.Current surveys and collected evidences find predicted factors including fetal fibronectin（fFN）,insulin-like growth factor binding protein-1（IGFBP-1）,serum relaxin（SRLX） and multiple proteins in maternal serum,amniotic fluid and cervical secretions to predict preterm labour.The usage of tocolysis decreases the odds of delivery within 48 hours,but has not consistently been shown to improve neonatal and perinatal outcomes.A delay of delivery for 48 hours allows for corticosteroid administration or maternal transfer.Adrenergic beta-agonists,calcium channel blockers,magnesium sulfate,oxytocin antagonists,progesterone and cyclooxygenase inhibitors may provide alternative choices for the treatment of preterm.The author reviewed the progress in prediction and therapeutics of preterm to assess the predicted factors and available tocolytic agents in clinical applications.
出处
《国际妇产科学杂志》
CAS
2013年第3期226-229,共4页
Journal of International Obstetrics and Gynecology
关键词
早产
危险因素
硫酸镁
肾上腺素能Β激动剂
Premature birth
Risk factors
Magnesium sulfate
Adrenergic beta-agonists
