摘要
目的在Beagle犬的下前牙建立牙周炎模型,探讨邻牙牙周炎对即刻种植体的影响。方法选6只健康成年Bea-gle犬,随机分成2组,A组犬作为对照组,定期进行菌斑控制,B组为实验组,下颌前牙进行丝线结扎,建立牙周炎模型。4周后A、B组同时拔除下颌双侧第二前磨牙,即刻植入种植体,种植体愈合4周后,行二期手术,连接基桩。自连接基桩后开始观察,分别于第1、2、3、4、5、6、7、8周进行各项临床检查,X线片观察种植体周围组织情况。结果随着时间进展,观察种植体8周后,种植体周围袋探诊深度(PPD):A组为(1.700±0.200)mm,B组为(5.083±0.133)mm;改良龈沟出血指数(mSBI):A组为0.000±0.000,B组为2.830±0.408;改良菌斑指数(mPLI):A组为0.170±0.408,B组为2.830±0.408;种植体龈沟液(PISF):A组为(0.752±0.043)mg,B组为(1.640±0.164)mg,对2组数据进行独立样本t检验,P<0.01,2组间各项临床指标都有显著性差异,X线片显示B组种植体周围出现不同程度骨吸收,所有B组种植体出现类似人类种植体周围炎的症状。结论 Beagle犬可成功建立牙周炎模型,下前牙的牙周炎与人类前牙的牙周炎症状极为相似,且可诱导远中种植体周围炎的自然发生,影响即刻种植体早期负荷的初期稳定性,该实验可为临床牙周炎患者的即刻种植研究提供一定帮助。
Objective To establish experimental periodontitis models in mandibular anterior teeth of beagle dogs,and to explore the influence of on immediately implants.Methods Six healthy adult beagle dogs were randomly divided into two groups：group A and group B.As a control group,dental plaque of group A was controled.Group B was experimental group.The silk ligatures would be forced into mandibular anterior teeth in order to establish periodontitis model.4 weeks later,extract bilateral mandibular second premolar was of all dogs at the same time,and place implants immediately.Second surgery was performed 4 weeks after implants healing.Clinical and radiographic recording was repeated at 1,2,3,4,5,6,7 and 8 weeks respectively after the abutments had been connected.Results As time passed,observation results of implants 8 weeks later was：PPD（peri-implant probing pocket depth）in group A（1.700±0.200）mm,group B（5.083±0.133）mm;mSBI（modified sulcus bleeding index）in group A（0.000±0.000）,group B（2.830±0.408）;mPLI（modified plaque index） in group A（0.170±0.408）,group B（2.830±0.408）,and PISF（peri-implant sulcular fluid） in group A（0.752±0.043）mg,group B（1.640±0.164）mg.Use independent sample t tests to compare the difference of the data,P〈0.01,and there was significant difference between two groups.The radiographc examination showed bone resorption to different degrees in group B,and all the experimental implants in group B demonstrated significantly symptoms similar to human peri-implantitis.Conclusions Experimental periodontitis models can be successfully established in beagle dogs.Periodontitis in mandibular anterior teeth of beagle dogs is similar to human periodontitis in mandibular anterior teeth.It can induce peri-implantitis of the distal implants naturally,and influence the incipient stability of early loading of immediate implants.The result of this experiment can provide some help for clinical research on immediate implants for periodontitis.
出处
《口腔医学》
CAS
2013年第6期383-388,共6页
Stomatology
关键词
牙周炎
即刻种植
动物模型
下颌前牙
BEAGLE犬
periodontitis
immediate implantation
animal model
mandibular anterior teeth
Beagle dogs
