摘要
目的研究大豆异黄酮对兰州地区绝经后妇女骨的影响。方法在兰州地区筛选出绝经后妇女60人,随机分为大豆异黄酮组(SIF)和对照组(Control),每人每天服用大豆异黄酮90 mg或者同等剂量安慰剂,时间6个月。抽血检测血清碱性磷酸酶和血清钙、磷,超声测定胫骨中段骨密度(BMD)。结果血清碱性磷酸酶显著下降(P<0.05),血清钙显著升高(P<0.05),胫骨中段BMD显著升高(P<0.05)。结论大豆异黄酮可增加绝经后妇女骨密度,减少骨量丢失。因而可以预防治疗骨质疏松症。
Objective To investigate the effect of soy isoflavone on bone mineral density in postmenopausal women. Methods Sixty postmenopausal women were selected in Lanzhou and randomly divided into 2 groups： soy isoflavone group （SIF） and control group （Control）. All subjects were given 90 mg/d isofalvone or placebo for 6 months. Serum AKP, calcium, and phosphate were detected. Bone mineral density （BMD） of the middle tibia was measured using ultrasound. Results Serum AKP in SIF group decreased significantly （ P 〈 O. 05 ） , while serum calcium increased significantly （ P 〈 0. 05 ）. BMD of the middle tibia increased significantly （ P 〈 0.05 ）. Conclusion Soy isoflavone can increase BMD and reduce bone loss in postmenopausal women, thus can be used for prevention and treatment of osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第6期616-618,共3页
Chinese Journal of Osteoporosis
关键词
大豆异黄酮
绝经后妇女
骨密度
Soy isoflavone
Postmenopausal women
Bone mineral density
