摘要
目的观察TPF方案与PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效及毒副反应。方法选取63例初诊的局部晚期鼻咽癌患者,随机分为试验组(TPF方案诱导化疗,31例)和对照组(PF方案诱导化疗,32例),诱导化疗2周期后均行同期放化疗,疗程结束后评价两组患者的近期疗效及毒副反应。结果两组的近期疗效比较差异无统计学意义(P=0.519),而试验组粒细胞减少的发生率显著高于对照组(P=0.020)。结论 TPF方案与PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效相当,其远期疗效有待于进一步研究。
Objective To compare the short-term efficacy and adverse reactions of TPF or PF neo-adjuvant chemotherapy com-bined with chemoradiotherapy in the treatment of locally advanced nasopharyngeal carcinoma. Methods Sixty three newly diagnosed locally advanced NPC patients were randomly divided into experimental group （TPF 31 case） and control group （PF 32 case）. After two cycles of neo-adjuvant chemotherapy, all the patients underwent concurrent chemoradiotherapy. The short-term efficacy and adverse reaction of both groups were evaluated at the end of＂ treatment. Results There were no significant differences in the short- term efficacy between the two groups （P=0.519）. The incidence of neutropenia significantly increased in experimental group, as compared with control group （P=0.020）. Conclusion TPF and PF neo-adjuvant chemotherapy combined with chemoradiotherapy had equal short-term clinical efficacy in the treatment of locally advanced nasopharyngeal carcinoma, while the long-term efficacies were still needed to be further researched.
出处
《肿瘤药学》
CAS
2013年第3期204-207,212,共5页
Anti-Tumor Pharmacy
关键词
局部晚期鼻咽癌
诱导化疗
放射疗法
多西紫杉醇
顺铂
氟尿嘧啶
Locally advanced nasopharyngeal carcinoma
Neoadjuvant chemotherapy
Radiotherapy
Docetaxel
Cisplatin
5-FU
