摘要
目的:观察TPF方案[多烯紫杉醇(TXT)+顺铂(CDDP)+氟尿嘧啶(5-FU)]联合放疗治疗晚期口腔鳞癌的疗效和毒副反应。方法:对48例晚期口腔鳞癌患者应用TPF方案进行治疗,其中TXT 70mg/m2,静脉滴入,d1给药;DDP 30mg/m2,静脉冲入,d1-3给药,5-FU 500-750mg/m2,静脉滴入,d1-5给药,21-28天为1周期,每例治疗2-3个周期后,给予总量为68.4Gy的常规放射治疗,具体为:每天1.8or2Gy,每周5天。结果:48例患者中总有效率(RR)为85.4(41/48),其中CR31.3(15/48),PR54.2%(26/48),SD12.5%(6/48),PD2.1%(1/48),中位生存期8.9个月(4-24个月),主要毒副反应为骨髓抑制及消化道反应。结论:TPF方案联合放疗治疗口腔鳞癌疗效确切,毒副反应可以耐受。
Objective：To evaluate the efficiency and toxicity of TPF regimen chemotherapy（Docetaxel＋Cisplatin ＋ fluorouracil） in the treatment of oral squamous cell carcinoma.Methods：Forty-eight patients were treated with TPF regimen,TXT 70mg/m2,ivdrip,d1 and d8;DDP 30mg/m2,iv,from d1 to d3,5-FU 500-750mg/m2 ivdrip from d1 to d5.The therapy was repeated every 21-28 days.Results：The overall response rate was 85.4（41 /48）,with CR 31.25（15 /48）,PR 54.16%（26/48）,SD12.5%（6/48）,and PD 2.08%（1/48）.The median overall survival of the whole group was 8.7 months（2-24 months）.The major toxicity and side effects were myelosuppression,nausea and vomiting.Conclusion：TPF regimen is effective for the advanced oral squamous cell carcinoma and the toxicity and side effects are tolerable.
出处
《现代肿瘤医学》
CAS
2010年第12期2358-2360,共3页
Journal of Modern Oncology
关键词
TPF方案
化放疗
多烯紫杉醇
顺铂
氟尿嘧啶
口腔鳞癌
TPF regimen chemoradiotherapy
docetaxel
cisplatin
fluorouracil
oral squamous cell carcinoma
