摘要
[目的]根据对LINGO-1在中枢神经系统疾病的相关信息进行了收集和分析,对其研究近况进行了综述。[方法]结合当前治疗中枢神经系统损伤性疾病的热点,总结LINGO-1的生理功能及在中枢神经系统损伤性疾病中的研究进展。[结果]LINGO-1是一种跨膜蛋白,在中枢神经系统(CNS)中有特异性表达,研究表明它对轴突再生和少突胶质细胞的增殖、成熟与髓鞘化等均有明显的抑制作用。[结论]进一步明确LINGO-1可作为促进轴突再生的有效新靶点。
[Objective]According to the collection and analysis on the information concerning present LINGO-1 in the central nervous system damage,it makes review on the study on LINGO-1.[Method] With the current treatment of central nervous system damage in disease hot spots,this article summa rizes the research progress of the physiological function of LINGO-1 disease in the central nervous system damage.[Result] LINGO-1 is a transmembrane protein,the specific expression in CNS;studies have shown that it is axonal regenerationand oligodendrocyte proliferation,mature and myelination signifi cantly inhibited.[Conclusion] Further clarifying the LINGO-1 can be used as effective new target to promote axonal regeneration.
出处
《浙江中医药大学学报》
CAS
2013年第6期835-838,共4页
Journal of Zhejiang Chinese Medical University
基金
上海市科委重点项目(064119515)
上海市卫生局项目(2010L072A)
海派中医流派传承研究基地颜氏内科基地(ZYSNXD-DD-HPCC-JD-007)~~
