热休克蛋白27、70在老年性白内障晶状体上皮细胞中的表达被引量：4

Expression of heat shock protein 27 and 70 in the epithelial cell of the age-related cataract lens

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摘要目的探讨热休克蛋白27(heat shock protein27,HSP27)和70(heat shock protein70,HSP70)在老年性白内障晶状体上皮细胞中的表达。方法采用免疫组织化学染色,检测老年性白内障晶状体前囊膜102例(其中皮质型36例,核型35例,后囊下型31例),正常人5例晶状体上皮细胞中HSP27、HSP70的表达。结果 HSP27、HSP70在老年性白内障和正常人晶状体上皮细胞中表达有显著性差异,老年性白内障组各亚型间HSP27、HSP70的表达也有显著性差异。结论 HSP27、HSP70可能在老年性白内障的发生、发展中起重要作用,且在皮质型、核型、后囊下型白内障发生的作用机制可能不完全相同。 Objective To investigate the expression of heat shock protein 27 （HSP27） and 70 （HSP70） in the epithelial cell of the age-related cataract lens. Methods The expression of HSP27 and HSPT0 in the epithelial cell of the age-related cataract lens （102 cases） and normal lens （5 cases） were detected by immunohistochemistry. Results The expression of HSP27 and HSPT0 in the epithelial cell of the age-related cataract lens were significantly higher than normal lens, and significant diffetence were found among the 3 groups of the age-related cataract lens. Conclusion HSP27 and HSP70 maybe play an important rote during the formation and development of age-related cataract, the mechanism are maybe different among corical cata- ract, nuclear cataract and subcapsular cataract.

作者陈爽赵清来

机构地区辽宁省大连市第五人民医院眼科

出处《中国现代药物应用》 2013年第13期10-11,共2页 Chinese Journal of Modern Drug Application

基金大连市卫生局资助课题

关键词热休克蛋白27、70(HSP27、HSP70) 老年性白内障晶状体上皮细胞 Heat shock protein 27 and 70（HSP27、HSP70） Age-related cataract len epithelial cell

分类号 R776.1 [医药卫生—眼科]

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