摘要
目的探讨ICU真菌感染的特点并分析氟康唑治疗的效果。方法回顾性分析我院ICU 120例真菌感染患者资料,对真菌感染的诱发因素、分布及种类进行分析;并分析氟康唑和两性霉素B对真菌感染的治疗效果和安全性。结果我院ICU真菌感染的发生率为8.23%,导致发生真菌感染的主要因素为侵入性操作如气管插管、机械通气、雾化吸入、长期使用抗生素和激素;ICU真菌感染常见于肺部,其次是泌尿生殖系统,其中白色念珠菌是主要的病原菌。观察组治疗有效率明显高于对照组(P<0.05),谷丙转氨酶、胆红素以及直接胆红素与对照组进行比较无统计学差异(P>0.05)。结论 ICU真菌感染有其自身特点和诱发因素;采用氟康唑早期治疗真菌感染疗效确切,无明显肝脏损害和不良反应。
Objective To explore the characteristics of ICU fungal infection, and analysis the effect of treatment with fluconazole. Methods Review of 120 cases of fungal infection in patients to our hospital treatment in ICU , analysed of predisposing factors, distribution and species of fungal infection,and compared with fluconazole and amphotericin B on the therapeutic effect and safety of the fungalinfection. Results The ICU of our hospital fungal infection was 8.23%,the main factors of fungal infection for invasive procedures such as endotracheal intubation, mechanical ventilation, inhala- tion, long-term use of antibiotics and hormones.ICU fungal infection was common in lung, followed by urinary and re- productive system, including Candida albicans is major pathogenic bacteria.The effective rate of treatment group was higher than that of control group （P 〈 0.05）, glutamic-pyruvic transaminase, bilirubin and direct bilirubin and control group showed no statistical difference （P 〉 0.05）. Conclusion ICU fungal infection has its own characteristics andfac tors;early treatment with fluconazole fungus infection have curative effect, and cannot find damage and adverse reaction.
出处
《中国现代医生》
2013年第18期158-160,共3页
China Modern Doctor
基金
国家自然科学基金(81101293)
