摘要
全球恶性肿瘤发病率中胃癌居第2位,近年来的研究不断证实Epstein-Barr(EB)病毒存在于胃癌细胞中,EB病毒相关胃癌(Epstein-Barr virus-associated gastric carcinoma,EBVaGC)逐渐被人们所了解和认知.全球胃癌患者中平均有7.5%是EBVaGC,预计每年有80000新增EBVaGC患者.EBVaGC具有自己独特的临床病理学特性,EB病毒编码的小RNA在肿瘤细胞中表达而不在正常上皮细胞中表达,说明EB病毒在胃癌的发生中起着重要的作用.本文对EB病毒及EBVaGC做一综述.
Gastric cancer ranks second among malignancies in terms of global incidence. Epstein-Barrvirus （EBV）-associated gastric carcinoma （EBVaGC） is a recently recognized entity, which is defined by the presence of EBV in gastric carcinoma cells. EBVaGC represents about 10% of gastric carcinoma cases worldwide. It is estimated that there are over 80000 new EBVaGC cases in the world annually. EBVaGC shows some distinct clinical and pathological characteristics. The observation that EBV-encoded small RNA is expressed in cancer cells but not in surrounding normal epithelial cells strongly suggests that EBV plays an etiological role in gastric carcinogenesis. In this review, we discuss the relationship between EBV and gastric carcinogenesis.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第17期1616-1622,共7页
World Chinese Journal of Digestology
