摘要
目的:探讨自体CIK细胞联合化疗对晚期胃癌患者的疗效。方法:62例经病理学确诊的晚期胃癌患者随机分为2组。对照组31例单纯接受2个周期DCF方案化疗,试验组31例接受化疗联合自体CIK细胞治疗。采用流式细胞术检测患者外周血T淋巴细胞亚群水平变化,影像学检查评价近期疗效,运用EORTCQLQ-C30测评量表分析患者生活质量改善情况。结果:与单纯化疗相比,接受自体CIK细胞联合化疗的患者细胞免疫功能较之前明显改善,其中CD3+CD56+T淋巴细胞较治疗前明显升高(4.4±0.6 vs.10.5±1.5,P=0.01)。近期疗效评价显示,两组的客观缓解率无明显差别,但试验组的疾病控制率较对照组明显提高(83.9%vs.61.3%,P=0.046)。生活质量测评显示,试验组患者的生活质量较对照组明显改善。患者躯体功能和总健康状况评分均较之前提高,气促、疲倦、疼痛、失眠、食欲丧失和恶心呕吐的症状评分均较之前降低。结论:自体CIK细胞联合化疗可有效提高晚期胃癌患者T淋巴细胞免疫功能、控制肿瘤生长、改善生活质量。
Objective：To evaluate the efficacy of autologous cytokine-induced killer（CIK）cells transfusion combined with chemotherapy in patients with advanced gastric cancer.Methods：Sixty-two patients with advanced gastric cancer were randomly divided into two groups.31 patients in control group received two cycles of chemotherapy of the regimen of DCF,31 patients in trial group treated with two cycles of chemotherapy in combination with autologous CIK cell transfusion.T-lymphocyte subgroups were separated and measured by flow cytometry Quality of life（QOL）was determined by EORTC QLQ-C30.The short-term curative effect was evaluated via imaging examinations.Results：T-lymphocyte immune activity was improved in patients received autologous CIK cell transfusion than those treated with chemotherapy alone.The subgroup of CD3＋CD56＋T lymphocyte was significantly increased（4.4±0.6 vs.10.5±1.5,P=0.01）.Short-term efficacy evaluation revealed that there was no significant difference in terms of objective response rate（ORR）between the two groups,but the disease control rate（DCR）was markedly increased（83.9% vs.61.3%,P=0.046）in the group treated by chemotherapy plus CIK cells compared to the group treated with chemotherapy alone.The QOL assessment suggested the quality of life in test group was obviously improved than that in the control group.Compared with the control group,patients treated with autologous CIK cell transfusion scored more in physical function and general health status,while the symptomatic scores in dyspnea,fatigue,pain,insomnia,loss of appetite and nausea and vomiting were significantly reduced.Conclusion：Autologous CIK cell transfusion combined with chemotherapy can effectively enhance the immune activity of T-lymphocytes,prevent disease progression and improve the quality of life in patients with advanced gastric cancer.
出处
《现代肿瘤医学》
CAS
2013年第7期1537-1540,共4页
Journal of Modern Oncology
基金
科技部重大新药创制创新药物研究开发技术平台建设基金项目(编号:2012ZXO9303016-002)
关键词
胃癌
细胞因子诱导的杀伤
免疫疗法
生活质量
gastric cancer
cytokine-induced killer
immunotherapy
quality of life
