摘要
目的利用磁共振波谱技术研究急性一氧化碳中毒(ACOP)患者及迟发性脑病(DEACMP)患者海马代谢物数值与正常对照组的差异,探讨其临床意义。方法所有实验者被分为3组:ACOP组17例、DEACMP组43例及正常对照组30名,并按年龄将3组分别分成年轻组(<50岁)和年老组(≥50岁)。所有病例均分别行双侧海马区磁共振波谱检查,采用单体素分辨自旋回波序列的点解析波谱法采集数据,记录双侧海马区氮-乙酰天门冬氨酸(NAA)/肌酸(Cr)、胆碱(Cho)/Cr值,采用独立样本t检验及单因素方差分析分组进行统计学分析。结果 (1)正常对照组左右两侧海马NAA/Cr、Cho/Cr差异均无统计学意义(年轻组NAA/Cr P=0.558、Cho/Cr P=0.566;年老组NAA/Cr P=0.546、Cho/Cr P=0.894)。(2)年轻组NAA/Cr数值:对照组、ACOP组、DEACMP组数值依次降低,差异有统计学意义(F=4.805,P=0.01)。(3)年轻组Cho/Cr数值依上顺序依次升高,差异有统计学意义(F=5.58,P=0.005)。(4)年老组NAA/Cr:对照组高于ACOP组与DEACMP组,差异有统计学意义(F=3.54,P=0.012);组内比较ACOP组与DEACMP组差异无统计学意义(P=0.512)。(5)年老组Cho/Cr:对照组低于ACOP组与DEACMP组,差异有统计学意义(F=3.931,P=0.026);组内比较对照组与ACOP组、ACOP组与DEACMP组差异均无统计学意义(P=0.684,P=0.479)。结论利用磁共振波谱技术可以准确反映ACOP患者急性期与迟发脑病期海马区代谢变化,为评估病情的严重性与早期诊断及预防DEACMP的发生提供理论支持。
Objective To evaluate the metabolic data and its clinical value of hippocampus in acute carbon monoxide poisoning（ACOP） and delayed encephalopathy after acute carbon monoxide poisoning（DEACMP） using 1^ H magnetic reso-nance spectroscopy. Methods The subjects were divided into 3 groups： ACOP group （17 cases）, DEACMP group （43 cases） and control group （30 cases）, also the subjectes were divided into 2 subgroups according to age： younger people （ 〈 50yrs） and aged people（≥50yrs）. All subjects underwent bilateral hippocampus MRS scans. Spectrum was collected by 2D 1^H MRS point resolved spectroscopy. NAA/Cr and Cho/Cr of bilateral hippocampus were recorded. Independent sample t test and single factor analysis were used for analyse. Results （ 1 ） There was no significant statistics difference between left and right hippocampus in control group（ younger people NAA/Cr P = 0. 558, Cho/Cr P = 0. 566;aged people NAA/Cr P = 0. 546,Cho/Cr P = 0. 894）. （2） For younger people, NAA/Cr showed descended in control, ACOP and DEACMP groups, and NAA/Cr had significant difference among groups （ F = 4. 805, P = 0.01 ）. （3） For younger people, Cho/Cr showed ascended in ontrol, ACOP and DEACMP groups, and Cho/Cr had significant difference among groups, （ F = 5.58, P =0. 005）. （4）For aged people, NAA/Cr in control group was higher than that of ACOP group and DEACMP group, which had significant difference （F = 3.54,P = 0. 012） , while there was no significant difference between ACOP group and DEACMP group （P =0. 512）. （5）For aged people, Cho/Cr in control group was lower than that of ACOP and DEACMP group, which had significant difference （F = 3.931 ,P = 0. 026） , while there was no significant difference between control group and ACOP group, or between ACOP group and DEACMP group （P = 0. 684,P = 0. 479）. Conclusion MRS could precisely reflect the hippocampus metabolic changes in the patients with ACOP and DEACMP. It will provide theoretical support for clinical evaluation, early diagnosis and the prevention of DEACMP.
出处
《临床放射学杂志》
CSCD
北大核心
2013年第6期770-774,共5页
Journal of Clinical Radiology
关键词
一氧化碳中毒
海马
磁共振成像
磁共振波谱
Carbon monoxide poisoning ,Hippocampus, Magnetic resonance imaging, 1^H-magnetic resonance spec-troscopy
