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代谢组学在慢性气道炎症性疾病中的研究进展 被引量：6

Application of metabolomics approaches to study of chronic respiratory inflammatory diseases
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摘要 代谢组学是研究生物体被扰动后内源性代谢物变化规律的系统科学，其在慢性气道炎症性疾病如支气管哮喘、慢性阻塞性肺疾病中的应用研究成为热点，有望通过对慢性气道炎症性疾病患者的代谢轮廓分析，寻找到有意义的生物标记物并探索疾病的发病机制。本文就研究现状作一综述，并展望其发展前景。 Metabolomics is a systematic science that mainly studies the dynamic changes of endogenous metabolites after a biological system is stimulated or disturbed. Its application in chronic respiratory inflammatory diseases like chronic obstructive pulmonary disease and asthma has increasingly been explored,with an attempt to find valuable biomarkers and explore the underlying pathogenesis of chronic respiratory inflammatory diseases by profiling the metabolism in these patients. This article summarizes recent advances in this topic and outlines prospects for future developments.
作者 厉蓓 董竞成
机构地区 复旦大学附属华山医院中西医结合科
出处 《国际呼吸杂志》 2013年第12期924-930,共7页 International Journal of Respiration
基金 基金项目：国家重点基础研究发展计划973计划项目（2009CB523000） 国家自然科学基金资助项目（81173390/H2902）
关键词 代谢组学 慢性气道炎症性疾病 支气管哮喘 慢性阻塞性肺疾病 Metabolomics Chronic respiratory inflammatory diseases Asthma Chronicobstructive pulmonary disease
分类号 R5 [医药卫生—内科学]
  • 相关文献

参考文献22

  • 1Fens N, de Nijs SB, Peters S, et al. Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD. Eur Respir J,2011,38:1301- 1309.
  • 2Oliver SG, Winson MK, Kell DB,et al. Systematic functional analysis of the yeast genome. Trends Biotechnol, 1998, 16 : 373-378.
  • 3Holgate ST, Holloway J, Wilson S,et al. Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities. J Allergy Clin Immunol, 2006,117 : 496-506.
  • 4Fireman P. Understanding asthma pathophysiology. Allergy Asthma Proc, 2003,24 : 79-83.
  • 5Holgate ST. Pathophysiology of asthma:what has our current understanding taught us about new therapeutic approaches? J Allergy Clin Immunol, 2011,128 : 495-505.
  • 6Saude EJ, Obiefuna IP, Somorjai RL, et al. Metabolomic biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance. Am J Respir Crit Care Med, 2009,179 : 25-34.
  • 7Saude EJ, Skappak CD, Regush S, et al. Metabolomie profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol, 2011,127 : 757-764.
  • 8Sofia M, Maniscalco M, de Laurentiis G, et al. Exploring airway diseases by NMR-based metabonomics: a review of application to exhaled breath condensate. J Biomed Biotechnol, 2011,2011 :403260.
  • 9Kerr JW. Identification of histamine metabolite 1-methyl, 4- imidazole acetic acid in human urine and its absence in status asthmatieus. Br MedJ,1964,2:606-608.
  • 10Mattarucchi E, Baraldi E, Guillou C. Metabolomics applied to urine samples in childhood asthma; differentiation between asthma phenotypes and identification of relevant metabolites Biomed Chromatogr, 2012,26 : 89-94.

二级参考文献16

  • 1孙理军,张登本,李怀东,张琪,于远望,陈震霖.大鼠脾虚模型的唾液免疫学研究[J].陕西中医,2004,25(7):665-666. 被引量：27
  • 2Peter J Barnes.慢性阻塞性肺疾病的治疗前景[J].中华医学杂志,2006,86(41):2884-2886. 被引量：17
  • 3慢性阻塞性肺疾病诊治指南(2007年修订版)[J].中华结核和呼吸杂志,2007,30(1):8-17. 被引量：8235
  • 4Spratlin JL, Serkova NJ, Eckhardt SG. Clinical applications of metabolomics in oncology: a review[ J ]. Clin Cancer Res, 2009, 15(2) : 431 -440.
  • 5Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica, 1999, 29(11) : 1181 -1189.
  • 6Bathen TF, Jensen LR, Sitter B, et al. MR-determined metabolic phenotype of breast cancer in prediction of lymphatic spread, grade, and hormone status [ J ]. Breast Cancer Res Treat, 2007, 104(2) : 181 -189.
  • 7Swanson MG, Zektzer AS, Tabatabai ZL, et al. Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy[J]. Magn Reson Med, 2006, 55(1): 1257 -1264.
  • 8Nicholson J K,Lindon J C,Holmes E,et al.Metabonomics:understanding the metabolic responses of living systems topathophysio-logical stimuli via multivariate statistical analysisof biological NMR spectroscopic data.Xenobiotica,1999,29 (11):1181-1189.
  • 9Henion J,Brewer E,Rule G.Sample preparation for LC/MS/MS:analyzing biological and environmental samples.Anal Chem,1998,70 (19):650-656.
  • 10Williams R,Lenz E M,Wilson A J,et al.Amulti-analytical platformapproach to the metabonomic analysis of plasma from normal andZuckerobeserats.MolBiosyst,2006,2(3-4):174-183.

共引文献57

同被引文献103

  • 1王桂珍,彭波,韩明向,李泽庚,韩宁林,张念志.化痰降气胶囊对慢性阻塞性肺疾病稳定期患者肺功能和血气分析的影响[J].中国中医急症,2006,15(12):1311-1312. 被引量：9
  • 2陆在英,钟南山.内科学[M].7版.北京:人民卫生出版社,2008:256-260.
  • 3Lemiere C, Ernst P, Olivenstein R, et al. Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilie and noneosinophilic phenotypes [ J ]. J Allergy Clin Immunol, 2006, 118 : 1033-1039.
  • 4Bel EH, Sousa A, Fleming L, et al. Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)[J]. Thorax, 2011,66: 910-917.
  • 5Carraro S, Rezzi S, Reniero F, et al. Metabolomics applied to exhaled breath condensate in childhood asthma E J ]. Am J Respir Crit Care Med, 2007, 175: 986-990.
  • 6Saude EJ, Obiefuna IP, Somorjai RL, et al. Metabolomie biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance[ J]. Am J Respir Crit Care Med, 2009, 179: 25 -34.
  • 7Saude EJ, Skappak CD, Regnsh S, et al. Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy [ J ]. J Allergy Clin Immunol, 2011, 127 : 757-764.
  • 8Mattarucchi E, Baraldi E, Guillou C. Metabolomics applied to urine samples in childhood asthma; differentiation between asthma phenotypes and identification of relevant metabolites[ J ]. Biomed Chromatogr, 2012, 26: 89-94.
  • 9Caldeira M, Perestrelo R, Barros AS, et al. Allergic asthma exhaled breath metabolome: a challenge for comprehensive two- dimensional gas chromatography [ J ]. J Chromatogr A, 2012,1254 : 87-97.
  • 10Adamko DJ, Sykes BD, Rowe BH. The metabolomics of asthma: novel diagnostic potential[ J]. Chest, 2012, 141: 1295-1302.

引证文献6

二级引证文献26

国际呼吸杂志
2013年 第12期

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