摘要
目的:探讨糖化血红蛋白(HbA1c)诊断农村中老年人群糖尿病(DM)及糖调节受损(IGR)的切点。方法:乐清市某社区为明确DM诊断而来院体检者和DM高危人群接受DM筛查者共749例,分为DM组141例、IGR组267例及糖代谢正常组(NGR组)341例,利用ROC曲线分析HbA1c诊断DM和IGR的最佳切点。结果:HbA1c诊断DM的最佳切点为6.1%,灵敏度和特异度分别为67.1%和83.7%。诊断IGR的最佳切点为5.8%,灵敏度和特异度分别为56.9%和56.1%。进一步分析显示,男性HbA1c诊断DM和IGR的最佳切点为6.1%和5.5%;而女性HbA1c诊断DM和IGR的最佳切点为6.3%和5.8%。结论:浙南农村中老年人群中,HbA1c诊断DM和IGR的最佳切点为6.1%和5.8%,低于美国糖尿病协会(ADA)的标准,且不同性别切点有差异。
Objective： To investigate the optimal glycated haemoglobin （HbA 1 c） cut-off points and evaluate the impact of HbAlc on diabetes disease （DM） and impaired glucose regulation （IGR） in middle-aged and elderly population. Methods： A total of 749 subjects, come from Yueqing of Wenzhou city, were enrolled in this study, including diabetes disease （DM）, impaired glucose regulation （IGR） and healthy individuals. The tests are compared by receiver operating characteristic curve （ROC）. Results： The 6.1% of HbAlc was recommend as a better cut-off value for diagnosis of DM in this population with its sensitivity and specificity as 67.1% and 83.7%. For IGR, the results showed low sensitivity （56.9%） and specificity （56.1%） with an AUC of 0.571 for HbAlc when 5.8% was used as the cut-off point. Furthermore, the optimal cut-off point of HbAlc for diagnosis DM and IGR was 6.1% and 5.5% for males, and 6.3% and 5.8% for females respectively. Conclusion： In middle-aged and elderly countryside population of Southern Zhejiang province, the optimum HbAlc cut-off point for DM and IGR was 6.1% and 5.8% respectively, which was lower than ADA criteria and might be different among males and females.
出处
《温州医学院学报》
CAS
2013年第6期375-378,共4页
Journal of Wenzhou Medical College
关键词
葡萄糖耐量试验
糖化血红蛋白
血糖
糖尿病
糖调节受损
glucose tolerance test
glycosylated hemoglobin
blood glucose
diabetes mellitus
impaired glucose regulation
