摘要
目的探讨血清巨噬细胞炎症蛋白-1α(MIP-1α)水平在川崎病(KD)患儿中的变化及其与冠状动脉扩张的相关性。方法选取急性期KD患儿30例,其中11例有急性期冠脉扩张;正常对照组20例。采用酶联免疫法检测血清MIP-1α水平,超声心动图检测冠状动脉扩张程度;分析血清MIP-1α水平变化及其与冠脉扩张程度的相关性。结果 KD急性期患儿的血清MIP-1α水平为(82.42±12.16)ng/L,高于正常对照组(37.22±3.41)ng/L,差异有统计学意义(P<0.05);冠脉扩张KD患儿的MIP-1α水平为(88.28±10.10)ng/L,高于冠脉正常KD患儿(73.61±1.26)ng/L,差异有统计学意义(P<0.05)。KD患儿血清MIP-1α水平与冠脉扩张程度呈正相关(r=0.452,P<0.05)。结论 KD急性期患儿的血清MIP-1α水平明显升高,而伴冠脉损伤的KD患儿的水平更高;MIP-1α水平与冠状动脉扩张程度呈正相关。
Objectives To detect serum MIP-1α level in children with Kawasaki disease （KD）, and to investigate the re1αtionship between MIP-1α and coronary artery di1αtation. Methods The levels of serum MIP-1α from 30 acute KD patients, among them 11 patients with coronary artery di1αtation, and 20 healthy children were detected by enzyme-linked immuno- sorbent assay. The degree of coronary artery di1αtation was detected by ultrasonic cardiogram and its association with MIP-Ia was performed. Results The level of serum MIP-1α in acute KD patients （82.42±12.16 ng/L） was obviously higher than that in healthy children （37.22±3.41 ng/L） （P〈0.05）. The level of serum MIP-1α in acute KD patients with coronary artery di1αta-tion （88.28±10.10ng/L） was higher than that in KD patients with non-coronary artery di1αtation （73.61±1.26 ng/L） （P〈0.05）. In addition, the level of serum MIP-1α in KD patients showed positive corre1αtion with the degree of coronary artery di1αta-tion （r=0.452, P〈0.05）. Conclusions The level of serum MIP-1α in KD patients is obviously higher and further higher in KD patients with coronary artery di1αtation. The serum MIP-1α level in KD patients shows positive corre1αtion with the degree of coronary artery di1αtation.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2013年第6期519-521,共3页
Journal of Clinical Pediatrics
关键词
川崎病
冠状动脉
巨噬细胞炎症蛋白-1Α
Kawasaki disease
coronary artery
macrophage inflammatory protein-1α
