摘要
目的 探讨 3-氧 -乙酰 - 11-脱氧甘草次酸铝 (aluminum 3-oxo -acetyl- 11-deoxogly cyrrhetinate,ADA)对实验性大鼠胃溃疡的保护作用机制。 方法 采用Shay结扎法、醋酸法复制大鼠胃溃疡模型 ,分别测定给药后胃粘液PGE2 含量及胃粘膜血流量 (GMBF) ,并对结果进行统计分析。结果 ADA5 0mg·kg-1,10 0mg·kg-1与对照组相比 ,能显著增加胃内游离粘液和胃壁粘液量及胃壁内PGE2 含量(P <0 .0 1)。连续以ADA灌胃能显著增加胃粘膜血流量 (P <0 .0 1)。结论 ADA的抗溃疡作用与增加胃粘液量 ,促进PGE2
Objective To research the protective effect and its mechanism of aluminum 3-oxo-acetyl-11-deoxoglycyrrhetinate (ADA) on experimental gastric ulcer in rats. Method Sparague-Dawley (SD) rats were replicated into gastric ulcer models by methods of pylous ligature and acetic acid. Gastric mucus content, gastric mucosal prostaglandin E 2 (PGE 2) and gastric mucosal blood flow (GMBF) were examined after drug respectively. The results were analyzed by statistic method. Results In compared with control group, ADA 50mg·kg -1 caused a significant increase in free and parietal mucus content (P<0.01) and markedly incresed the PGE 2 secretions of gastric mucosal (P<0.01). The consecutive administration of ADA (62.5mg·kg -1 , 125mg·kg -1 ) ig twice a day for 14d produced a significant increase in gastric mucosal blood flou (GMBF) (P<0.01).Conclusion The antiulcer action of ADA be related to increasing gastric mucus and PGE 2 secretion and GMBF.
出处
《新乡医学院学报》
CAS
2000年第1期5-6,9,共3页
Journal of Xinxiang Medical University
基金
河南省教委资助项目
关键词
脱氧甘草次酸铝
胃溃疡
粘液
前列腺素E2
aluminum 3-oxo-acetyl-11-deoxoglycyrrhetinate
gastric ulcer
mucus
prostaglandin E 2
gastric mucosal blood flow
