摘要
目的 研究溃疡散对实验性大鼠胃溃疡的保护作用机制。方法 Wistar大鼠 5 0只 ,随机分为 0 .5 %羧甲基纤维素钠组、西咪替丁 (0 .5 g·kg-1)阳性对照组、溃疡散 0 .35 g、0 .7g及 1.4g·kg-13个剂量组。给药 6d后采用幽门结扎法复制大鼠胃溃疡模型 ,分别测定胃液容量、胃酸含量、胃蛋白酶活性和胃壁粘液量。结果 溃疡散 0 .7g和 1.4g·kg-1组能明显减少胃液容量 (P <0 .0 5、P <0 .0 1)和降低胃总酸排出量 (P <0 .0 0 1) ;各剂量组均能显著降低胃蛋白酶活性 (P <0 .0 1)和增加胃壁粘液量 (P <0 .0 5 ) ;各种作用呈剂量依赖性。结论 溃疡散的抗溃疡作用与增强粘膜保护因素和减少对胃粘膜的损伤因素有关。
Objective To investigate the protective effect and its mechanism of Kuiyang powder on experimental gastric ulcer in rats. Methods Fifty Wistar rats were divided randomly into 5 groups, control group(0.5% sodium carboxymethyl cellulose), positive contral group(cimitidine 0.5g·kg -1 ), and three groups of Kuiyang powder (0.35g·kg -1 , 0.7g·kg -1 and 1.4 g·kg -1 Kuiyang powder). After six days, Wistar rats were replicated into gastric ulcer models by pylorus ligation. The gastric juices content, gastric acid, peptic activity and parietal mucus content were measured after 6 days of drug-taking respectively. Results Kuiyang powder 0.7g·kg -1 and 1.4g·kg -1 caused a obvious decrease of gastric juices(P<0.05, P<0.01) and gastric acid secretion(P<0.001).In every group of Kuiyang powder the peptic activity was decreased and the parietal mucus content increased obviously. All actions appeared dose-dependent. Conclusion The antiulcer action of Kuiyang powder is related to increased the protective factors and decreased the disruptive factors of gastric mucous.
出处
《新乡医学院学报》
CAS
2000年第4期250-251,253,共3页
Journal of Xinxiang Medical University
基金
河南省科委立项课题!(No .96 12 0 10 19)
关键词
溃疡散
实验性胃溃疡
胃酸
胃蛋白酶
中药
药理
Kuiyang powder
experimental gastric ulcer
gastric acid
pepsin parietal mucus
