摘要
目的比较小剂量垂体后叶素加心痛定与生长抑素治疗肝硬化曲张静脉破裂出血的有效性和安全性。方法２９例垂体后叶素加心痛定治疗者，先以垂体后叶素１０ｕ稀释静注，继以每小时１．６～１．７ｕ静滴４８小时，再依次每小时静滴 １．２～ １．３，０．８～０．８５和０．４～０．４５ｕ各２４小时。同时每６小时舌下含服心痛定 １０ｍｇ。 １７例生长抑素治疗者，先静注生长抑素１００ｕｇ，继以每小时１０～１２，６～８和４ｕｇ分别连续静滴４８，２４和４８小时。结果在４８小时内，全组总出血控制率为７６％，其中垂体后叶素加心痛定治疗组为８６％，高于生长抑素治疗组的５８％（Ｐ＜０．０１）。停药后一周再出血率分别为前者的８％和后者的３０％（Ｐ＜０．０５）。两组均未见明显副反应。结论小剂量垂体后叶素加心痛定可有效地治疗肝硬化曲张静脉破裂出血，优于生长抑素，且副反应小，价格低，使用方便，适合各级医疗单位临床应用。
Objective To compare the effectiveness and safety of low dosage pituitrin and nifedipine with somatostatin in the treatment of variceal hemorrhage in liver cirrhosis. Methods 29 cases were treated with pituitrin and nifedipine while another 17 cases with somatostatin. Results Within 48 hours, the total stanching rate was 76%, in which the stanching rate in the pituitrin and nifedipine group was 86% while in the somatostatin group the stanching rate was 58 % (P < 0. 01). One week after the withdraw of the drug, the rebleeding occurrence was 8% in the pituitrin and nifedipine group and 30% in the somatostatin group wce (P < 0. 05). No apparent side effects were observed in both groups. Conclusion Low dosage of pituitrin and nifedipine could effectively and safely control variceal hemorrhage, superior to somatostatin with the advantages of fewer side effects, lower cost and easier to use.
出处
《浙江临床医学》
2000年第6期361-362,共2页
Zhejiang Clinical Medical Journal
关键词
肝硬化
曲张静脉破裂出血
垂体后叶素
心痛定
Liver cirrhosis Variceal hemorrhage Pituitrin Nifediprine Somatostatin
