摘要
目的探讨结直肠癌患者根治术前CEA、CA19-9水平对预后的预测价值。方法回顾性分析复旦大学附属肿瘤医院2003年12月至2007年1月间491例接受根治性切除的Ⅱ、Ⅲ期结直肠癌患者临床资料,包括患者术前血清CEA和CA19-9水平、临床病理资料及预后情况。利用单变量和多变量分析患者年龄、性别、肿瘤部位、肿瘤分化、TNM分期、肿瘤侵犯深度及淋巴结转移个数与预后的关系。结果患者术前血清CEA和CA19-9水平、TNM分期、淋巴结转移数、肿瘤侵犯深度、肿瘤的分化都与预后相关。在多变量分析中,CEA和CA19-9水平、TNM分期、肿瘤分化是总生存的独立预测因素,CA19-9水平、TNM分期、肿瘤分化是无病生存的独立预测因素。结论术前血清CA19-9与CEA水平均对结直肠癌患者的预后有预测价值。CA19-9水平应该作为常规的术前检查指标,对CEA检测结果有补充作用。
Objective To assess the prognostic value of preoperative serum CEA and CA19-9 in colorectal cancer. Methods We retrospectively reviewed consecutive patients with stage II and III colon cancer treated with curative surgery alone from December 2003 to January 2007 in Cancer Center of Fudan University. Patient demographics, levels of CEA and CA19-9, clinical, histopathologic, and prognostic data were recorded. The relationship between age, gender, tumor location, differentiation, TNM stage, depth of invasion, number of lymph-nodes metastasis and prognosis were analyzed by univariate and multivariate analysis. Results CEA, CA19-9, TNM stage, number of lymph nodes metastasis, depth of invasion and differentiation were correlated with prognosis. In Cox＇s univariate analysis, CEA, CA19-9, TNM stage and differentiation were independent significant prognostic factors for overall survival（OS）. Otherwise, CA19-9, TNM stage, differentiation were independent prognostic factors for disease free survival （DFS）. Conclusions CA19-9 provides a prognostic parameter in eolorectal cancer and can not be replaced by CEA. CA19-9 should be used in the routine examination before operation, especially in combined use with CEA.
出处
《中华结直肠疾病电子杂志》
2012年第2期13-17,共5页
Chinese Journal of Colorectal Diseases(Electronic Edition)
