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快速右室起搏犬心脏整体及局部心肌功能的变化 被引量:5

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摘要 目的探讨快速右室起搏犬心脏整体及局部心肌收缩、舒张功能的变化。方法选取健康成年杂种犬13只,制作快速右室起搏犬模型。分别于起搏前和起搏4周后(关闭起搏状态30 min)常规超声检测其舒缩功能指标,应用应变成像技术检测起搏前后左室侧壁、前壁、下壁和室间隔基底段及中间段的心内膜下各点心肌的收缩期峰值应变(PSS)、舒张期峰值应变(PDS)。结果与起搏前比较,起搏4周后犬模型左室舒张末期内径、左室收缩末期容积和左室舒张末期容积均增加(P均<0.01),并伴有左室射血分数的减低(P<0.01);左室室间隔、侧壁、下壁以及前壁的基底段、中间段PSS和以上左室四壁在左室二尖瓣环处4个位点的心肌收缩速度峰值也明显降低(P<0.05或<0.01)。左室四壁基底段和中间段的PDS明显降低(P<0.01)。结论短期快速的右室起搏不仅导致临床上发生充血性心力衰竭和左室整体、局部心肌收缩功能的异常,而且伴有舒张功能异常和局部心肌运动的不协调。
出处 《山东医药》 CAS 2013年第13期44-47,共4页 Shandong Medical Journal
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