摘要
目的研究颈动脉粥样硬化斑块形成与缺血性脑血管病（ICVD）的相关性。方法选择126例缺血性脑血管疾病患者根据动脉粥样硬化斑块出现的脑血管支数分为无斑块组（A组，41例）、1～2支存在斑块组（B组，45例），3支及3支以上存在斑块组（C组，40例），对各组总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）、尿酸（UA）及纤维蛋白原（Fib）的水平进行比较。同时据缺血性脑血管疾病的分类，将126例患者分为单发性脑梗死组（42例）、多发性脑梗死组（46例）及TIA组（39例），对不同部位动脉粥样硬化斑块面积比较。结果3支及3支以上存在斑块组的TC、TG、LDL—C、UA、Fib水平显著高于无斑块组及1～2支存在宽块组（P均〈0．05），而HDL-C水平显著低于无斑块组及1～2支存在斑块组（P〈0．05）。多发性脑梗死患者的颈总动脉（CCA）主干部及膨大部、颈内动脉（ICA）起始部位粥样硬化班块面积显著大于单发性脑梗死组及TIA组患者（P均〈0．05）。结论TC、TG、LDL—C、UA、Fib水平的上升与HDL—C水平的下降能提高颈动脉斑块形成的危险程度，同时和动脉粥样硬化斑块的病变的支数呈正比。颈动脉粥样硬化斑块的面积增大能提高ICVD的发生率，同时与脑梗死的严重情况呈正相比。
Objective To study the correlation of carotid atherosclerotic plaque formation with ischemic eerebrovascular disease. Methods One hundred and twenty-six patients with cerebrovascular disease were divided into two groups according to atherosclerotie plaque count, patients with no atherosclerotic plaque were in group A（41 cases） , patients with atherosclerotic plaque counts of 1 -2 were in group B（45 cases） , patients with atherosclerotie plaque counts of more than 3 were in group C （40 cases）. The level of total cholesterol（YC）, triglyeerides （ TG）, low density lipoprotein cholesterol （ LDL- C）, high-density lipoprotein cholesterol （ HDL-C）, uric acid （ UC）, and fibrinogen （Fib） of the three groups were compared. At the same time, the 126 patients were divided into single stroke group（42 cases）, multiple cerebral infarction group （46 cases）, TIA group （39 cases） according to classification of ischemic cerebrovascular disease, atherosclerotic plaque area of the three groups were compared.Results The level of TC, TG, LDL-C, and Fib of group C were higher than the other two groups, while the level of HDL-C were lower than the other two groups significantly （ P 〈 0. 05 ）. The atherosclerotic plaque area of CCA truck and enlargement parts and ICA initiation site of multiple cerebral infarction group were larger than the other two groups significantly （ P 〈0. 05）. Conclusions The elevated level of TC, TG, LDL-C, UA and Fib and the decreased level of HDL-C increases the risk of carotid atherosclerotic plaque formation, and are positively correlated with counts of carotid atherosclerotic plaque. The increases of carotid atherosclerotic plaque area increases the incidence of ICVD and are positively correlated with severity of cerebral infarction.
出处
《中国实用医刊》
2013年第12期38-40,共3页
Chinese Journal of Practical Medicine
关键词
缺血性脑血管病
动脉粥样硬化
颈动脉
斑块
相关性
Ischemic cerebrovascular disease
Atherosclerosis
Carotid artery
Plaque
Correlation
