摘要
芬太尼族药物包括芬太尼、瑞芬太尼、舒芬太尼和阿芬太尼等,已广泛用于临床麻醉及术后镇痛。肾功能不全患者常伴有贫血、低血容量和低蛋白血症,许多药物不良反应发生率明显高于肾功能正常者。肾功能不全时芬太尼族药物的吸收、分布、生物转化和排泄等都可能发生改变。总结分析对肾功能不全患者芬太尼族药物药动学研究的进展,有助于指导临床用药,减少药物不良反应。
Fentanyl, rerifentanil, sufentauil, and alfe^anil are the fentanyl family＂ of drugs. They have been widely used in clinical anesthesia and postoperative analgesia. Patients with renal inadequacy often have anemia,hypovolemia and hypoproteinemia, the incidence of adverse drug reactions in patients with renal inadequacy is significantly higher than in patients with the normal renal function. The absorption, distribu- tion,biotransformation and excretion of fentanyl family of drugs may change in patients with renal failure. Here is to make a review of pharmacokinetics of the fentanyl family of drugs in patients with renal failure and provide guidance for clinical medication, reducing adverse drug reactions.
出处
《医学综述》
2013年第11期2045-2047,共3页
Medical Recapitulate
