摘要
目的:探讨中西医结合治疗晚期结直肠癌临床疗效。方法:选择2010年1月到2012到6月在本院治疗的63例晚期结直肠癌患者,按随机抽样的方法分为对照组31例患者和研究32例患者,对照组给予FOLFOX6化疗方治疗方案,研究组在对照组治疗的基础上,联合自拟复方中药治疗。治疗两个疗程,比较两组患者治疗效果、疼痛评分(NRS)、生活质量评分(FACT)。以及治疗前后患者血清癌胚抗原(CEA),糖链抗原19-9(CA199)的变化。结果:研究组疗效(84.3%)明显高于对照组(64.5%),差异显著(P<0.05)。两组治疗后,研究组疼痛评分(NRS)下降、生活质量评分(FACT)增加,与对照组比较差异显著(P<0.05)。与治疗前比较,治疗后两组患者血清CEA,CA199均明显下降,差异显著(P<0.05);治疗后,与对照组患者血清CEA,CA199比较,研究组明显改善(P<0.05)。结论:中西医结合治疗晚期结直肠癌术效果明显,值得临床推广。
Objective： To explore the clinical curative effect of traditional Chinese and western medicine combination for the treatment of advanced colorectal cancer.Method： Choose 63 cases of the patients with advanced colorectal cancer from January 2010 to 2012 June in our hospital.According to the random sampling method,divided into the control group witn 31 cases and research group with 32 cases.Control group given FOLFOX6 chemotherapy treatments,the rearch group on the basis of the control group treatment,combination with traditional Chinese medicine treatment,after two treatments,compared of the treatment effect of two groups,pain score numerical rating scale（NRS）,the life quality score FACT,and the patients serum carcinoembryonic antigen（CEA） and sugar chain antigen 19-9（CA199） change before and after treatment.Result： Compared with curative effect（64.5%）,the team curative effect（84.3%） increased significantly（P ＆lt; 0.05）.After the treatment of the two groups,the pain score NRS decline,the life quality score FACT increase（P ＆lt; 0.05）.After the treatment,the two groups of patients serum CEA and CA199 were significantly decreased,significant difference,there is statistical significance（P ＆lt; 0.05）.After the treatment,compared to the control group patients serum CEA and CA199 comparison,the rearch group obviously improved（P ＆lt; 0.05）.Conclusion： Combine traditional Chinese and western medicine combination for the treatment of advanced colorectal cancer operation the effect is obvious and it is worth clinical promotion.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第12期323-325,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
中西医结合
晚期结直肠癌
疗效观察
traditional Chinese and western medicine combination
advanced colorectal cancer
curative effect observation
