摘要
目的分析前交叉韧带重建术后关节感染的特点及相关因素,调查使用万古霉素浸泡自体肌腱移植物预防前交叉韧带重建术后感染的有效性,为降低前交叉韧带重建术后感染率。方法回顾性分析2002年10月-2012年10月1056例患者前交叉韧带重建术后感染率,将其分为最初5年,504例患者围手术期使用抗菌药物预防感染(A组),随后5年,552例患者除围手术期使用抗菌药物外,术中加用万古霉素浸泡肌腱(B组),使用χ2检验,比较两组患者术后感染率。结果 A组504例患者,术后发生感染8例,感染率1.6%,细菌培养检出表皮葡萄球菌5株、金黄色葡萄球菌2株、琼氏不动杆菌1株;B组552例患者中无1例发生感染,两组比较,差异有统计学意义(P<0.05)。结论万古霉素浸泡移植肌腱,可有效降低前交叉韧带重建术后感染率。
OBJECTIVE To analyze the characteristics and related factors of infections after the reconstruction of anterior cruciate ligament （ACL） and investigate the effectiveness of vaneomycin presoaked autografts in preven- tion of the postoperative infections so as to reduce the incidence of infections after the reconstruction of ACL. METHODS This was a retrospective analysis of data that were prospectively collected for 1056 patients who under went anterior cruciate ligament reconstruction （ACLR） from Oct 2002 to Oct 2012. In the initial 5 year period, 504 patients （the group A） underwent ACLR with preoperative intravenous （IV） antibiotics. In the subsequent 5- year period, 552 patients underwent ACLR with a vancomycin-presoaked grafts （the group B） plus preoperative IV antibiotics, then the chi-square test was performed to compare the incidence of postoperative infections between the two groups. RESULTS In group A, the postoperative infections occurred in 8 of 504 patients with the infection rate of 1.6%, and there were 5 strains of Staphylococcus epidermidis, 2 strains of Staphylococcus aureus, and 1 strain of Acinetobacter junii isolated through the bacterial culture; there was no case of patients with infections among the 552 patients, the difference between the two groups was statistically significant （P 〈 0. 05）. CONCLUSION Prophylactic vancomycin presoaked grafts can effectively reduce the incidence of infections after ACLR.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第12期2986-2987,2990,共3页
Chinese Journal of Nosocomiology
基金
浙江省教育厅科研项目(Y201226171)
关键词
万古霉素
预防
前交叉韧带重建
感染
Vancomycin
Prevention
Anterior cruciate ligament reconstruction
Infection
