摘要
目的观察盐酸氨溴索静脉滴注治疗急性脑卒中相关性肺炎（sAP）的效果。方法选取2011年7月至2012年12月我院收治的诊断为SAP的82例老年急性脑卒中患者，随机分为盐酸氨溴索组43例和对照组39例，盐酸氨溴索组进行盐酸氨溴索并联合抗生素治疗，对照组则仅给予相应抗生素治疗，比较两组患者的退热时间、住院时间、抗生素使用时间、c反应蛋白、动脉血氧分压，以及细菌清除率、治疗有效率等。结果盐酸氨溴索组患者的退热时间、住院时间、抗生素使用时间分别为（3．1±0．8）d、（11．7±3．7）d、（5．4±1．7）d，均短于对照组（3．8±1．1）d、（13．6±4．9）d、（6．6±2．1）d（t=18．60、22．80、23．50，P=0．014、0．008、0．011），细菌清除率90．7％、总有效率93．0％，高于对照组74．4％和74．4％（X^2=3．86、5．34，P=0．05、0．02）。两组患者治疗后血清C反应蛋白和动脉血氧分压差异无统计学意义（均P〉0．05）。结论盐酸氨溴索静脉滴注治疗急性脑卒中相关性肺炎，可缩短抗生素使用时间，缩短病程，有效清除细菌，较对照组疗效更明显。
Objective To observe the clinical effects of ambroxol on acute stroke-associated pneumonia （SAP）. Methods From July 2011 to December 2012, a total of 82 patients with stroke- associated pneumonia （SAP） admitted to our hospital were selected and randomly divided into ambroxol group （n= 43, treated with ambroxol in combination with antibiotic therapy ） and control group （n=39, treated with antibiotic therapy）. The defervescence time, hospitalization time, antibiotic use time, C-reactive protein level, blood oxygen partial pressure, bacterial clearance rate and the total effective rate were compared between the two groups. Results The defervescence time, hospitalization time, antibiotic use time were shorter in ambroxol group than in control group [（3. 1± 0.8）dvs. （3.8±1.1）d, （11. 7±3.7）dvs. （13.6±4.9）d, （5.4±1. 7）dvs. （6.61±2.1）d,t 18.60, 22.80, 23.50, P=0. 014, 0. 008, 0. 011, repectively]. Bacterial clearance rate and the total effective rate were higher in ambroxol group than in control group [90.7% vs. 74.4%, 93.0% vs. 74.4% ,）C2 = 3.86, 5.34, P = 0.05, 0. 021. There were no significant differences in changes of C-reactive protein level and blood oxygen partial pressure between two groups before and after treatment （all P〉0.05）. Conclusions Ambroxol is an effective treatment for acute stroke associated pneumonia, which can shorten antibiotic use time and duration of symptoms and remove bacteria effectively.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第6期621-623,共3页
Chinese Journal of Geriatrics
关键词
氨溴索
卒中
肺炎
Ambroxol
Stoke
Pneumonia
