摘要
丙氨酸氨基转移酶(alanine aminotransferase,ALT)主要存在于组织细胞中,以肝细胞中含量最多,正常时主要存在于肝细胞胞浆的可溶部分,只有在肝细胞膜损伤或细胞溶解坏死时ALT才能大量释放入血。因此,ALT升高通常被认为是肝脏炎症的指示性标记物[1]。ALT是临床评价乙型肝炎(乙肝)
Hepatitis B virus (HBV) infection is one of the major health problems worldwide. Serum alanine aminotransferase (ALT) level is the most commonly used indicator to assess the degree of the liver inflamma- tion of chronic hepatitis B (CHB) patients. More and more reports found that not all patients with normal ALT levels have low fibrosis scores in their liver biopsy. In this review, we summarize and discuss the hepatic pathology and the therapy of CHB with persistent normal ALT.
出处
《中国病毒病杂志》
CAS
2013年第3期166-170,共5页
Chinese Journal of Viral Diseases
基金
广东省医学科研基金项目(201103132)
关键词
乙型肝炎病毒
病理学
免疫耐受
非活动复制
Hepatitis B virus
Pathology
Immune tolerance
Non-active replication