摘要
目的探讨慢性乙型肝炎患者肝细胞内HBcAg分布规律与血清病毒学指标的相关性。方法对958例慢性乙型肝炎患者的血清学、病毒学、免疫组织化学等资料进行对比分析。结果在肝细胞内HBcAg不同分布类型之间,血清HBeAg阳性率及HBV DNA载量均存在显著性差异(χ2值分别为364.01和417.41,P<0.001)。其中,此两项指标以HBcAg核型和混合型分布组最高,HBcAg阴性组最低,而HBcAg浆型分布组的HBeAg阳性率及HBV DNA载量则介于上述两组之间。结论 HBcAg在受染肝细胞内的分布与血清病毒学指标之间具有明显的相关性,随着HBcAg分布态势由受染肝细胞核向细胞浆漂移到最终不能检测到,HBeAg阳性率及HBV DNA载量呈逐渐降低的趋势。
Objective To study the relationships between subcellular localization of HBcAg in hepatocytes and markers of HBV replication in serum in patients with chronic hepatitis B. Methods All of 958 CHB patients were divided into 4 groups according to the HBeAg subcellular location in hepatocytes. Data of HBeAg positive rates and HBV DNA levels were compared, respectively. Results Significant differences of HBeAg positive rates and HBV viral load were determined among 4 groups （X^2 = 364.01 and 417.41, P 〈 0. 001 ）. Higher HBeAg positive rate and HBV DNA level were detected in the groups which HBeAg distributed in nucleus or both nucleus and cytoplasm while the lowest in the group of negative HBcAg. The group which HBcAg distributed in cytoplasm lies between the above groups. Conclusions The subeellular localization of HBcAg in hepatocytes may associate with the markers of HBV replication in serum. With HBcAg shifting from nucleus to cytoplasm and finally being deleted, the HBeAg positive rates and HBV DNA levels decreased gradually.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2011年第1期42-45,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
