摘要
目的研究降钙素原（PCT）水平在开颅术后颅内感染诊断中的价值。方法收集开颅术后颅内感染患者fn=201和非颅内感染患者（n=201的脑脊液和血液样本，检测脑脊液和血清PCT，脑脊液和血液白细胞计数等指标并进行统计分析。结果感染组脑脊液和血清PCT水平、脑脊液白细胞计数较非感染组显著升高，差异有统计学意义（P〈0．05）。脑脊液PCT和白细胞计数诊断敏感性较高（95％、90％），脑脊液和血清PCT诊断特异性较高（90％、80％）。脑脊液PCT和脑脊液白细胞计数及血清PCT呈显著正相关（F0．729，仁0．000；r=0．679，P=-0．000）。结论脑脊液PCT、脑脊液白细胞计数和血清PCT在颅脑手术术后颅内感染的诊断中均有意义，其中脑脊液PCT较脑脊液白细胞计数误诊率更低，较血清PCT敏感性更高，临床应用价值更大。
Objective To explore the diagnostic value of cerebrospinal fluid procalcitonin （PCT） level in intraeranial infection after craniotomy. Methods Forty post-craniotomy patients with suspicious intracranial infection were chosen in our study; these patients were divided into infected and disinfected group （n=20）. PCT and white blood cell （WBC） counts in the serum and cerebrospinal fluid were detected and analyzed, respectively. Results Both PCT and WBC values in the cerebrospinal fluid and serum in the infected group were significantly higher than those in the disinfected group （P〈 0.05）. Both PCT and WBC in the CSF had good sensitivity, and PCT in the cerebrospinal fluid and serum had high specificity. Correlation analysis indicated that CSF WBC and serum PCT were positively correlated to CSF PCT （r=0.729, P=0.000; r=0.679, P=0.000）. Conclusion CSF PCT could be proposed as an effective diagnostic marker for intracranial infection and it is superior to serum PCT and WBC count.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2013年第6期621-624,共4页
Chinese Journal of Neuromedicine
基金
国家临床重点建设专科资助项目
关键词
颅内感染
降钙素原
白细胞计数
脑脊液
Intracranial infection
Procalcitonin
White blood cell count
Cerebrospinalfluid
