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酒精依赖伴抑郁障碍给予度洛西汀与帕罗西汀治疗的临床对比分析

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摘要 目的分别应用度洛西汀与帕罗西汀对病患酒精依赖伴抑郁障碍进行治疗,研究两种药物的治疗效果。方法选取2011年6月至2012年11月来本院进行酒精依赖伴抑郁障碍治疗的118例病患作为研究对象,按照随机原则,将病患分为治疗组和对照组,每组59例,对治疗组病患采用度洛西汀进行治疗,对照组病患采用帕罗西汀进行治疗,对比治疗前后有效率、不良反应发生情况、汉密尔顿抑郁量表评分情况、治疗费用、病患满意情况等指标。结果治疗组有效率为86.44%,对照组有效率为84.75%,治疗组汉密尔顿抑郁量表评分比对照组略低,两组治疗费用接近,有效率、汉密尔顿抑郁量表评分以及治疗费用三个指标P>0.05,不存在统计显著性差异;治疗组2例发生不良反应,对照组有6例发生不良反应,治疗组病患满意度比对照组好,并且不良反应发生情况以及病患满意情况指标P<0.05,存在统计显著性差异。结论度洛西汀与帕罗西汀效果类似,均比较优良,但是度洛西汀不良反应更少,更为安全可靠。
出处 《中国医药指南》 2013年第11期609-610,共2页 Guide of China Medicine
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  • 1Michael J, Detkea MD, Yill L, et al. Duloxetine 60rag once daily dosing versus placebo in the acute treatment of major depression[J]. Journal of Psychiatric Research, 2002,36(6) : 383-390.
  • 2David J, Goldstein MD. Duloxetine in the treatment of major depressive disorder: a double-blind clinical triM[J]. J Clin Psychiatry, 2003,63(9): 225-231.
  • 3Detke MJ,Lu Y,Goldstein DJ,et al. Demitrack MA Duloxetine,60mg once daily,for major depressive disorder:a randomized double-blind placebo-controlled trial[J]. Clin Psychiatry,2002,63(4):308.
  • 4Gerber PD, Barrett JE, Barrett JA, et al. The relationship of presenting physical complaints to depressive symptoms in primary care patients[J]. J Gen Intern Med, 1992,7 (2) : 170.
  • 5Goldstein D J, Lu Y, Detke M J, et al. Effects of duloxetine onpainful physical symptoms associated with depression[J]. Psychosomatics, 2004,54(4) : 17.
  • 6Mallinckrodt CH, Goldstein D J, Detke M J, et al. Duloxetine: a new treatment for the emotional and physical symptoms of depression[J]. Prim Care Companion J Clin Psychiatry,2003,5( 1 ) : 19.
  • 7Hirschfeld RM, Vomik LA. Newer antidepressants: reviews of efficacy and safety of escitalopram and duloxetine [J]. J Clin Psychiatry, 2004,65 ( suppl 4 ) : 46.
  • 8Kurt K, Robert LS, Janet BW. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms[J]. Psychosomatic Medicine, 2002,64 (2) ..258.
  • 9Detke MJ, Lu Y, Goldstein DJ, et al. Duloxetine, 60 mg once daily, for major depressive disorder: a randomized doubleblind placebo-controlled trial[J]. J Clin Psychiatry, 2002,63 (4) : 308.
  • 10Lesley MA, Yili L, Leslie JC, et al. A doubleblind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder[J]. Arthritis Rheumatism, 2004, 50 (9):2 974.

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