摘要
本文报道螨类接种于豚鼠气管后引起的肺部病变,并比较了5种常见贮藏螨(椭圆食粉螨、纳氏皱皮螨、粉尘螨、腐食酪螨、粗脚粉螨)的致病性。发现接种螨后6天豚鼠肺部已形成典型的结节性病灶,结节圆锥形呈淡黄色,直径1～5mm;镜下病灶表现为细支气管炎和细支气管周围炎,肺实质内有明显的异物肉芽肿形成,炎症在螨类接种于豚鼠20天时,肺部未见嗜酸粒细胞浸润,但30或40天时则出现明显的嗜酸粒细胞浸润。细支气管周围小动脉受到损害,部分小动脉内可见到螨体残骸。在实验室分别培养了环境中常见的5种螨,并分别接种于5组豚鼠的气管,结果证明这5种螨具有相似的致病性。上述事实说明豚鼠可作为研究肺螨病的适宜动物模型。
Typical nodular foci were found in the lungs of guinea-pigs six days after mites were in jected into the tracheae. The foci were found in all part of the lobes. They were yellow in fresh tissues and arranged from one to five millimeters in diameter. The pathological changes were present mainly as brochiol and peribrochiol lesions. The eosinophile infiltration was not seen in the lungs 20 days after mites were injected into the tracheae, but the eosinophile infilteration was obvious 30 days later. Multiple multinucleate giant cells were present. There was a striking formation of foreign body granuloma and involvment of blood vessels. The parasitic mites were usually found in some arterioles. The study demonstrated that the guinea-pigs may be used as the animal model for the study of pulmonary acariasis. Five species of common stored mites were reared under laboratory condition and were injected respectively into windpipes of 5 groups of guinea-pigs. The results showed that the 5 common stored mites were possed of similar pathogenesis.
出处
《地方病通报》
1991年第1期42-45,136-137,共4页
Endemic Diseases Bulletin
关键词
肺螨病
螨
动物模型
病理学
Pulmonary acariasis
Mite
Animal model
Guinea-pig
Pathology
Pathogenesis
