摘要
本文通过螨类接种家兔气管进行动物实验的观察、患者免疫球蛋白IgE测定及嗜碱粒细胞脱颗粒试验和其它实验室检查,探讨肺螨病的致病机理,结果表明实验动物肺部产生了特征性病变,并发现螨类经气管接种后20天时,肺部未见有嗜酸性粒细胞的浸润,而于接种40天后肺部见有明显的嗜酸粒细胞浸润;患者血清IgE显著增高;嗜碱粒细胞脱颗粒反应多呈阳性,提示本病的致病机理除螨类寄生于肺部所致的机械性损伤外,与螨体或其代谢抗原所引起的免疫病理反应密切有关。
About 200 Iiving mites were injected into the trachea of rabbits to form the animal model of pulmonary acariasis. Observations were carried out on some immunologic index and immuno- reaction on the animal model and developed patients of pulmonary acariasis. It was shown that some distinctive lesions developed in the rabbits' lung tissue, and both the blood eosinophil and total serum IgE were increased. In most of the patients, human basophile degranulation test (HBDT) was found to be positive.The results suggest that the pathogenic mechanism of pulmonary acariasis is referable to two factors; mechanical injuries caused by para-siting mites and the allergic reaction.
出处
《蚌埠医学院学报》
CAS
1990年第3期183-185,共3页
Journal of Bengbu Medical College
关键词
肺螨病
致病机理
pulmonary acariasis
pathogenic mechanism
