中国人VEGF基因多态性与DR的关系被引量：3

The association study of gene polymorphism of vascular endothelial growth factor with diabetic retinopathy

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摘要目的:探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)I/D基因多态性与糖尿病视网膜病变(diabetic retinopathy,DR)的关系。方法:应用PCR-RFLP方法检测91例2型糖尿病患者和30例对照者的VEGF I/D基因和VEGF水平。结果:NPDR组和PDR组DD基因型频率显著高于NDR组和对照组(P<0.01);NPDR组和PDR组血清VEGF水平显著高于NDR组和对照组(P<0.01)。结论:VEGF I/D基因多态性很可能与DR的发生发展有关,D等位基因可能是DR的易感基因。 AIM： To investigate the correlation of vascular endothelial factor （VEGF） I/D gene polymorphism with diabetic retinopathy（DR） in type 2 diabetes mellitus. METHODS： The 91 patients with diabetes and 30 control cases which VEGF I/D genotypes and VEGF level were determined by polymerase chain reaction - restriction fragment length polymorphism（PCR-RFLP）. RESULTS： The DD genotype frequencies were significantly higher in NPDR and PDR groups than in groups of NDR and control （P〈 0.01 ） ; The VEGF level were significantly higher in NPDR and PDR groups than in groups of NDR and normal control（ P〈0.01 ）. CONCLUSION： VEGF I/D gene polymorphism is associated with the development of diabetic retinopathy; D allele is probably a susceptible gene of diabetic retinopathv.

作者李东豪胡利何文智丘红红闻毅颐杨倩

机构地区广州医学院第三附属医院眼科广州医学院第三附属医院妇研所实验室

出处《国际眼科杂志》 CAS 2013年第6期1106-1107,共2页 International Eye Science

基金广州市荔湾区科技计划项目(No.20111213068)~~

关键词血管内皮生长因子基因多态性糖尿病视网膜病变 vascular endothelial growth factor genepolymorphism diabetic retinopathy

分类号 R587.1 [医药卫生—内分泌] R774.1 [医药卫生—眼科]

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参考文献5

1Buraczynska M, Ksiazek P, Baranowicz-Gaszczyk I, et al. Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients. Nephrol Dial Transplant 2007; 22(6) : 827-832.
2Ray D, Mishra M, Ralph S, et al. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes 2004;53(3) :861-864.
3Awata T, Inoue K, Kurihara S, et al. A common polymorphism in the 50-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 2002 ;51 (4) : 1635 - 1639.
4王晓梅,金成吉,张弢,杨晓辉,冯海娟,于晓静,曲健梅.血管内皮生长因子基因多态性与糖尿病视网膜病变的相关性[J].中国糖尿病杂志,2008,16(8):462-464. 被引量：5
5Witmer AN, Vrensen GF, Van Noorden CS, et al. Vascular endothelial growth factor angangiogenesis in eye disease. Prog Eye Res 2003 ;22(2) : 1-29.

二级参考文献5

1Awata T,Inoue J,Kurihara S, et al. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes, 2002, 51:1635-1639.
2Duh E, Aiello LP. Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox. Diabetes, 1999,48: 1899-1906.
3Witmer AN,Vrensen GF,Van Noorden CJ,et al. Vascular endothelial growth factor and angiogenesis in eye disease. Prog Eye Res,2003,22:1-29.
4Ray D,Mishra M, Ralph S, et al. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes, 2004,53 : 861-864.
5Watson CJ, Webb NJ, Bottomeley MJ, et al. Indentification of polymorphism within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine, 2000,12 : 1232-1235.