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长链非编码RNA在肿瘤中作用的研究及进展 被引量：6

Research and progress of long non-coding RNA in tumor
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摘要 作为转录产物的长链非编码RNA(long non-coding RNA,lncRNA),在小鼠全cDNA文库的大规模基因测序中首次被描述。随着研究的深入,其重要功能逐渐为人们所认知。lncRNA不仅是一个简单的信使角色,更具有精细结构和重要的转录及信息储备功能。本文着重讨论目前对长链非编码RNA的认识以及长链非编码RNA在肿瘤发生、发展中的作用。 Long non-coding RNA（lncRNA）,as a transcription product,was firstly described in a large-scale gene sequencing of the mouse cDNA library.With further research,its important function was gradually understood.lncRNA is not only a simple messenger role,but also a fine structure,important transcription function and information reserve.This article will focus on the current understanding of the long non-coding RNA and the development of long non-coding RNA in tumor.
作者 何烨 王科明
机构地区 南京医科大学第二附属医院
出处 《现代肿瘤医学》 CAS 2013年第6期1381-1383,共3页 Journal of Modern Oncology
基金 江苏省"科教兴卫工程"创新团队与领军人才资助项目(编号:LG201126) 南京医科大学第二附属医院2012年度院级创新团队资助项目(编号:Z201204)
关键词 长链非编码RNA 肿瘤 研究进展 long non-coding RNA tumor research progress
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献21

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二级参考文献3

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共引文献14

同被引文献49

  • 1周晓东,吕农华.大肠癌的流行病学研究现状[J].现代消化及介入诊疗,2006,11(3):149-151. 被引量：72
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  • 6KotakeY, Nakagawa T, Kitagawa K, et al. Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 (INK4B) tumor suppressor gene. Oncogene, 2011, 30: 1956-1962.
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  • 8Yang Z, Zhou L, Wu LM, et al. Overexpression of long non- coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol, 2011, 18: 1243-1250.
  • 9Yap KL, Li S, Munoz-Cabello AM, et al. Molecular interplay of the noneoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell, 2010, 38~ 662-674.
  • 10Yang F, Zhang I, Hno XS, et al. Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology, 2011, 54: 1679-1689.

引证文献6

二级引证文献26

现代肿瘤医学
2013年 第6期

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