摘要
目的:研究WT1在子宫内膜病变中的表达规律及其在子宫内膜癌的发生、预后评估中的临床价值。方法:免疫组化法(S-P)检测增生期、分泌期正常子宫内膜各5例做为对照组。子宫内膜单纯性增生10例、非典型增生33例、子宫内膜癌40例,共83例做为实验组,观察WT1在正常子宫内膜及不同子宫内膜病变中的阳性表达。结果:WT1在内膜单纯性增生、非典型增生中阳性表达与对照组比较无统计学差异(P>0.05)。WT1在子宫内膜腺癌中的表达明显升高,与对照组比较有统计学意义(P<0.01)。WT1阳性表达率与子宫内膜癌的手术-病理分期(P<0.05)、组织分化程度(P<0.05)、淋巴转移(P<0.05)有关。结论:WT1与子宫内膜癌的发生、发展密切相关,WT1表达增加提示子宫内膜病变恶性程度高。
Objective：To evaluate the value of expression of WT1 in endometrial lesions and endometrial cancer prognosis.Methods：Immunohistochemistry（S-P） was ased to detect the expression of WT1 in proliferative phase,secretory phase endometrium in 5 cases as control group,10 cases with endometrial hyperplasia and 33 cases of atypical hyperplasia,40 cases with carcinoma of endometrium,a total of 83 cases as experimental group.Results：The expression of WT1 in endometrial hyperplasia atypical proliferation have no statistical difference between the control group and experimental group（P0.05）.The expression of WT1 obviously increased in endometrial carcinoma（P0.01） compared with control group.The positive rate of WT1 was correlated with clinical phase（P0.05）,grade of cellular differentiation（P0.05） and lymphonode metastasis（P0.05）.Conclusion：WT1 closely related to the occurrence,development of endometrial cancer,increased expression of WT1 in endometrium lesions was with high degree of malignancy.
出处
《现代肿瘤医学》
CAS
2013年第6期1310-1313,共4页
Journal of Modern Oncology
基金
辽宁省科学技术厅资助项目(编号:2011404013-8
20102266)
辽宁省教育厅资助项目(编号:L2010642)
沈阳市科学技术局资助项目(编号:F12-227-1-62)
