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非小细胞肺癌中EphA2、NET-1的表达及意义 被引量：4

Expressions and significance of EphA2 and NET-1 in non-small cell lung cancer(NSCLC)
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摘要 目的:探讨非小细胞肺癌(NSCLC)中EphA2、NET-1的表达及意义。方法:采用免疫组织化学SP法,检测60例NSCLC及10例正常肺组织(对照组)中EphA2、NET-1的表达。结果:EphA2、NET-1在NSCLC中的阳性表达率(80.00%、85.00%)明显高于癌旁正常肺组织(20.00%、30.00%)。EphA2、NET-1蛋白在NSCLC中的表达差异与患者性别、年龄、病变部位无关(P>0.05),但与NSCLC组织的分化程度、临床分期、有无淋巴结转移相关(P<0.05)。结论:EphA2、NET-1在NSCLC中的高表达可促进肿瘤细胞的转化、增殖、迁移,可作为临床判定肺癌恶性程度的指标。 Objective：To explore the expressions and significance of EphA2 and NET-1 in NSCLC.Methods：SP immunohistochemical staining was used to examine the expressions of EphA2 and NET-1 in 60 NSCLC specimens and 10 normal lung tissues.Results：The positive rates of EphA2 and NET-1 in lung cancer（80.00% and 85.00%） were significantly higher than those in the normal tissue（20.00%and 30.00%）.EphA2 and NET-1 expressions were not correlated with age,sex and tumor position（P0.05）,but correlated with differential,clinical stage and lymph nodes metastasis（P0.05）.Conclusion：The high expressions of EphA2 and NET-1 in NSCLC could promote the tumor cells＇ transformation,multiple and moving,and may be an useful tool for providing information about the malignant degree.
作者 邵伟伟 兰建云 宋曙 邹琳
机构地区 盐城市第一人民医院病理科
出处 《现代肿瘤医学》 CAS 2013年第6期1260-1262,共3页 Journal of Modern Oncology
关键词 非小细胞肺癌 EPHA2 NET-1 NSCLC EphA2 NET-1
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献12

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共引文献12

同被引文献51

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引证文献4

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现代肿瘤医学
2013年 第6期

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