摘要
目的:探讨肿瘤相关蛋白TSPAN-1与Ki-67在宫颈癌组织中表达及其关联性。方法:应用免疫组织化学SP法检测正常宫颈、宫颈癌及宫颈内瘤样病变(CIN)组织(各30例)中TSPAN-1及Ki-67蛋白的表达。结果:正常宫颈、CIN和宫颈癌组织中TSPAN-1和Ki-67的阳性表达率分别为0(0/30)、36.7%(11/30)、73.3%(22/30)和13.3%(4/30)、53.3%(16/30)、80.0%(24/30),差异有统计学意义(χ2=34.737和27.036,P均<0.001),宫颈癌和CIN组织高于正常宫颈组织。宫颈癌组织中TSPAN-1表达与淋巴结转移有关(P=0.014)。宫颈癌组织中TS-PAN-1与Ki-67表达有关联性(χ2=8.960,rP=0.539,P<0.001)。结论:TSPAN-1过表达与细胞增殖有关,参与宫颈癌的发生发展。
Aim：To study the expression levels of tetraspanin-1（TSPAN-1） and Ki-67,and their relationship in cervical cancer.Methods：The expression levels of TSPAN-1 and Ki-67 proteins in normal cervix tissue,cervical cancer tissue and cervical intraepithelial neoplasia tissue （CIN） （each n=30） were detected by the immunohistochemical SP method.Results：The positive expression rate of TSPAN-1 and Ki-67 were 0,36.7%,7.33%,and 13.3%,53.3%,80.0% in the three groups,and there were obvious differences（χ2=34.737 and 27.036,P0.001）.The expression of TSPAN-1 and Ki-67 proteins increased progressively from normal cervix to CIN and to cervical carcinoma（P0.05）.The expression of TSPAN-1 was related to the lymph node metastasis status （P=0.014）.In cervical carcinoma,the expression levels of TSPAN-1 and Ki-67 were associated （χ2=8.960,rp=0.539,P0.001）.Conclusion：The overexpression of TSPAN-1 is closely related to the proliferation and contribute to the oncogenesis of cervical cancer.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2010年第3期469-471,共3页
Journal of Zhengzhou University(Medical Sciences)
