大剂量化疗联合自体造血干细胞移植一线治疗弥漫大B细胞淋巴瘤
被引量:2
摘要
目的探讨大剂量化疗联合白体外周血造血干细胞移植一线治疗中高危及高危弥漫大B细胞淋巴瘤的疗效。方法31例中高危及高危弥漫大B细胞淋巴瘤患者使用化疗诱导缓解治疗达部分缓解(PR)或完全缓解(CR)后,行自体外周血造血干细胞移植下大剂量化疗。结果31例患者中位随访时间49个月,5年总生存率(OS)72.0%,5年无病生存率(DFS)56.0%。结论自体外周血干细胞移植支持下大剂量化疗一线治疗中高危及高危弥漫大B细胞淋巴瘤疗效确切。
出处
《中国医师杂志》
CAS
2013年第5期679-681,共3页
Journal of Chinese Physician
参考文献12
-
1Seki H, Ohshima, Fujisaki T, et al. Prognostic impact of immuno-histo- chemical biomarkers in diffuse large B-cell lymphoma in theRituximab era . Cancer Sci ,2009 ,100( 10) : 1842-1847.
-
2Van Imhoff GW,van der Holt B,Mackenzie MA, et al. Impact ofthree courses of intensified CHOP prior to high-dose sequentialtherapy followed by autologous stem-cell transplantation as first-linetreatment in poor-risk, aggressive non- hodgkin^s lymphoma : com-parative analysis of Dutch-Belgian Hemato- Oncology CooperativeGroup Studies 27 and 40. J Clin Oncol,2005,23 ( 16): 3793-3801.
-
3Haioun C, Mounier N, Quesnel B, et al. Tandem autotransplantas first-line consolidative treatment in poor-risk aggressive lympho-ma: a pilot study of 36 patients. Ann Oncol,2001,12( 12) : 1749-1755.
-
4Feugier P, van H, Sebban C, et al. Long-term results of the R-CHOP study in the treatment of elderly patients with diffuse LargeB-cell lymphoma : A study by the groupe dEtude des lymphoma del'Adulte . J Clin Oncol, 2005,18 (23) :41174126.
-
5牛家华,王椿,万理萍,颜式可,姜杰玲,杨隽,蔡宇.不同方案治疗弥漫大B细胞淋巴瘤的疗效及预后分析[J].中华血液学杂志,2010,31(10):706-708. 被引量:3
-
6Greb A, Bohlius J, Trelle S, et al. High-dose chemotherapywithautologous stem cell support in first-line treatment of aggressivenon-Hodgkin lymphoma-results of a comprehensive meta-analysis .non-Hodgkin lymphoma-results of a comprehensive meta-analysis. Cancer Treat Rev, 2007, 33(4): 338-346.
-
7Tarella C, Zanni M, Di Nicola M, et al. Prolonged survival inpoor-risk diffuse large B-cell lymphoma following front-line treat-ment with rituximab-supplemented,early-intensified chemotherapywith multiple autologous hematopoietic stem cell support : a multi-center study by GITIL ( Gruppo Italiano Terapie Innovative neiLinfomi). Leukemia,2007,21(8): 1802-1811.
-
8Vranovsky A, Ladicka M, Lakota J. Autologous stem cell trans-plantation in first-line treatment of high-risk aggressive non-Hodgkin ,s lymphoma. Neoplasma ,2008,55 (2) :107-112.
-
9Papajik T, Raida L, Faber E. High-dose therapy and autologousstem cell transplantation in patients with diffuse large B-cell lym-phoma in first complete or partial remission. Neoplasma, 2008,55(3):215-221.
-
10Vitolo U, Chiappella A. Dose-dense and high-dose chemotherapyplus rituximab with autologous stem cell transplantation for prima-ry treatment of diffuse large B-cell lymphoma with a poor progno-sis: a phase II multicenter study. Haematologica, 2009,94 ( 9 ):1250-1258.
二级参考文献45
-
1蔡宇,王椿,杨隽,颜式可,蔡琦,高彦荣,姜杰玲.抗CD_(20)单克隆抗体在非霍奇金淋巴瘤治疗中的应用[J].白血病.淋巴瘤,2005,14(3):145-147. 被引量:8
-
2Tilly H, Lepage E, Coiffier B, et al. Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma [J]. Blood, 2003,102:4284-4289.
-
3Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma [J]. N Engl Med, 1995,333: 1540-1545.
-
4Gianni AM, Bregni M, Siena S, et al. High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma[J]. N Engl J Med, 1997,336: 1290-1297.
-
5Haioun C, Lepage E, Gisselbrecht C, et al. Survival benefit of high-dose therapy in poor-risk aggressive non-Hodgkin's lymphoma. Final analysis of the prospective LNH87-2 protocol- A Group d'Etude des Lympboma de l'Adulte Study[J]. J Clin Oncol, 2000, 18 : 3025-3030.
-
6Martelli M, Gherlinzoni F, de Renzo A, et al. Early autologous stem-cell transplantation versus conventional chemotherapy as front-line therapy in high-risk, aggressive non-Hodgkin's lymphoma: An Italian multicenter randomized trial [J]. J Clin Oncol, 2003,21 : 1255-1262.
-
7Milpied N, Deconinck E, Gaillard F, et al. Initial treatment of aggressive lymphoma with high-dose chemotherapy and autologous stem-cell support[J]. N Engl J Med, 2004,350: 1287-1295.
-
8Rodriguez J, Caballero MD, Gutierrez A, et al. High-dose chemotherapy and autologous stem cell transplantation in peripheral T-cell lymphoma:The GEL-TAMO experience [J]. Ann Oncol, 2003,14: 1768-1775.
-
9Kurnick NB, Montano A, Gerdes JC, et al. Preliminary observations on the treatment of postirradiation hematopoietic depression in man by the infusion of stored autologous bone marrow [J]. Ann Intern Med, 1958,49:973-986.
-
10Appelbaum FR, Herzig GP, Ziegler JL, et al. Successful engraftment of cryopreserved autologous bone marrow in patient with malignant lymphoma [ J ]. Blood, 1978,52 : 85-95.
共引文献5
-
1李虎生,张华.自体外周血造血干细胞移植治疗恶性淋巴瘤的研究进展[J].华夏医学,2010,23(3):321-325. 被引量:4
-
2喻凤宽,周健,李玉富,张龑莉,房佰俊,符粤文,宋永平.BEAC预处理自体造血干细胞移植治疗淋巴瘤的疗效观察[J].肿瘤防治研究,2011,38(11):1324-1325. 被引量:2
-
3彭翠翠,刘林,文静.利妥昔单抗联合APBSCT治疗B细胞性非霍奇金淋巴瘤的临床研究[J].重庆医学,2014,43(28):3718-3721. 被引量:3
-
4刘瑜,王劲,曾艳,彭翠翠.自体外周血造血干细胞移植术治疗弥漫大B细胞淋巴瘤的临床研究[J].实用临床医药杂志,2015,19(11):12-14. 被引量:6
-
5高畅,王腾,吕纯懿,徐瑞荣.基于数据挖掘探析徐瑞荣治疗弥漫大B细胞淋巴瘤的用药规律[J].湖南中医杂志,2025,41(1):20-25.
同被引文献25
-
1钟梅,吕亚莉,李冰,赵坡.用IgH、TCR基因重排技术检测疑难淋巴组织增生性病变[J].肿瘤防治研究,2006,33(1):42-43. 被引量:4
-
2朱少君,李艳红,张伟,王姝妹,巩丽,兰淼.基因重排检测技术诊断脾脏淋巴瘤[J].第四军医大学学报,2007,28(15):1411-1414. 被引量:3
-
3Webb IJ,Friedberg nW,Gribben JG,et al.Effective purging of autologous hematopoietic stem cells using anti-B-cell monoclonal antibody-coated high-density microparticles prior to high-dose therapy for patients with non-Hodgkin 's lymphoma[J].Biol Blood Marrow Transplant,2002,8 (8):429-434.
-
4Kojima K,Kaneda K,Yasukawa M,et al.Specificity of polymerase chain reaction-based clonality analysis of immunoglobulin heavy chain gene rearrangement for the detection of bone marrow infiltrate in B-cell lymphoma-associated haemophagocytic syndrome[J].Br J Haematol,2002,119(3):616-621.
-
5Philip T,Guglielmi C,Hagenbeek A,et al.Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma[J].N Engl J Med,1995,333 (23):1540-1545.
-
6Vranovsky A,Ladicka M,Lakota J.Autologous stem cell transplantation in first-line treatment of high-risk aggressive nonHodgkin's lymphoma[J].Neoplasma,2008,55 (2):107-112.
-
7Tarella C,Zanni M.Prolonged survival in poor-risk diffuse large B-cell lymphoma following front-line treatment with rituximabsupplemented,early-intensified chemotherapy with multiple autologous hematopoietic stem cell support:a multicenter study by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi)[J].Leukemia,2007,21 (8):1802-1811.
-
8Freedman AS,Neuberg D,Mauch P,et al.Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma[J].Blood,1999,94(10):3325-3333.
-
9Friedberg JW,Kim H,Li S,et al.Ex vivo B cell depletion using the Eligix B Cell SC system and autologous peripheral blood stem cell transplantation in patients with follicular non-Hodgkin's lymphoma[J].Bone Marrow Transplant,2003,32(7):681-686.
-
10周红平,饶兆英,曾毓华,李招金.小儿急性淋巴细胞白血病IgH及TCR γ基因重排研究[J].实用癌症杂志,1999,14(2):111-113. 被引量:2
引证文献2
-
1易嘉宁,谢承霖,马莹,汪欣宇,张冉,易平勇,欧阳周,姚远.淋巴瘤外周造血干细胞IgH及TCRγ基因重排的检测及临床意义[J].中国医师杂志,2014,16(8):1109-1112. 被引量:1
-
2张莹,张琪,刘倩,李庭,李爱敏.King互动达标理论的心理护理在弥漫大B细胞淋巴瘤患者自体外周血造血干细胞移植围术期的应用[J].临床心身疾病杂志,2020,26(1):162-165. 被引量:11
二级引证文献12
-
1李莉,王绪芝,裴如梦.基于King达标理论的心理干预对子宫内膜癌化疗患者心理韧性的影响[J].心理月刊,2021(21):29-31. 被引量:2
-
2岳姣姣,邢玉荣.分析延续护理弥漫大B细胞淋巴瘤患者对生存质量和护理满意度的影响[J].航空航天医学杂志,2021,32(12):1532-1534. 被引量:2
-
3江梦天,尹建平,张义成,马威,杨茹.自体造血干细胞移植治疗复发难治性B细胞NHL的效果及其影响预后相关因素的分析[J].中国实验血液学杂志,2018,26(5):1366-1371. 被引量:4
-
4丁玲.基于King互动达标理论的多学科团队合作在老年半髋关节置换术后康复的应用[J].蚌埠医学院学报,2021,46(9):1304-1308. 被引量:26
-
5周婷,何莉丽,魏冉,孙文玲,王曼利,宋明桧.基于个案分析的护理干预对淋巴瘤骨髓移植患者术后感染的影响[J].当代护士(中旬刊),2021,28(12):58-60. 被引量:3
-
6陈娟,张小敏,刘姗姗,陈玉红.互动达标理论主导的延续性护理在心脏移植术后的应用研究[J].中国实用护理杂志,2022,38(9):659-666. 被引量:35
-
7任维,王莉,潘蕊,段婷婷,吕娅.心理护理干预对首次干细胞捐献者不良反应预防作用的效果分析[J].中国卫生标准管理,2022,13(8):160-163. 被引量:1
-
8庞文利,李海燕.护理干预对造血干细胞移植患者术前焦虑的影响[J].中外医疗,2022,41(14):181-185. 被引量:2
-
9叶蓉.全程护理管理对外周血造血干细胞采集质量及患者不良反应的影响[J].国际护理学杂志,2022,41(19):3609-3612. 被引量:3
-
10徐辉,张丽.身心并重共护延伸护理在弥漫大B细胞淋巴瘤化疗患者中的应用[J].保健医学研究与实践,2023,20(3):84-87. 被引量:13
-
1王磊.表柔比星联合多西紫杉醇对晚期乳腺癌近期疗效的临床观察[J].中国实用医药,2014,9(18):147-148. 被引量:4
-
2高旭,徐振宇,孙颖浩.前列腺癌的辅助治疗及新辅助治疗[J].中华泌尿外科杂志,2004,25(6):429-431. 被引量:5
-
3龚芳泽,孙显明,陈琦,袁钟,李红,刘春梅.根据第六天骨髓象调整老年人急性髓性白血病诱导缓解治疗[J].贵州医药,1998,22(3):191-192.
-
4孟凡义.成人急性淋巴细胞白血病的治疗现状[J].中国肿瘤,2000,9(11):503-505. 被引量:1
-
5梁良,王晓珊,刘迪.不同化疗方案对乳腺癌近期疗效的影响[J].中国肿瘤临床与康复,2014,21(3):299-301. 被引量:6
-
6贾琦.两种新辅助化疗方案治疗乳腺癌的近期疗效和不良反应比较[J].哈尔滨医药,2012,32(3):196-197. 被引量:5
-
7孙颖浩,高旭.前列腺癌内分泌治疗的合理选择[J].继续医学教育,2007,21(6):12-14. 被引量:1
-
8郭玉霞,徐酉华.全反式维甲酸相关多药耐药机制及其逆转的研究进展[J].儿科药学杂志,2007,13(6):54-57.
-
9王秀桂,符英金.急性白血病诱导缓解治疗效果的预测方法[J].中国热带医学,2003,3(2):175-176.
-
10张亮,陈立军,王亚林,赵立.舒尼替尼联合自体DC及CIK细胞治疗转移性肾癌的临床疗效观察[J].解放军医学杂志,2013,38(12):980-983. 被引量:12